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Invitrogen
RIM2 Polyclonal Antibody
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Product Details
PA5-20522
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
A 17 amino acid peptide near the center of the human Rim2.
Conjugate
Form
Liquid
Concentration
1 mg/mL
Amount
100 µg
Purification
Antigen affinity chromatography
Storage buffer
PBS
Contains
0.02% sodium azide
Storage conditions
Maintain refrigerated at 2-8°C for up to 3 months. For long term storage store at -20°C
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
A suggested positive control is rat brain tissue lysate.
PA5-20522 can be used with blocking peptide PEP-0642.
Target Information
Rab3-interacting molecules (RIMs) are synaptic proteins necessary for neuronal transmission and plasticity. Rim1 and Rim2 proteins are expressed in overlapping but distinct patterns throughout the brain. While the ablation of either gene was not lethal in mice, the deletion of both resulted in postnatal mortality. This lethality is due to a defect in neurotransmitter release; synapses without RIM proteins can still release neurotransmitters but are unable to do so in response to normal Ca2+ triggers. Like Rim1, Rim2 is thought to be an effector protein for Rab3, binding to Rab3 on synaptic vesicles in a GTP-dependent manner.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: non-small cell lung cancer RIM2; non-small cell lung cancer RimL3a protein; non-small cell lung cancer RimL3c protein; nuclear protein; Rab-3-interacting molecule 2; Rab-3-interacting protein 2; Rab-3-interacting protein 3; Rab3 interacting protein 1; Rab3 interacting protein 2; RAB3 interacting protein 3; rab3-interacting molecule 2; Rab3-interacting protein; rab3-interacting protein 2; Regulating synaptic membrane exocytosis protein 2; RIM 2; RIM2 (CT); synaptic exocytosis regulator 2; synaptotagmin 3, related sequence; unnamed protein product
Gene Aliases: 2810036I15Rik; AW048769; CRSDS; KIAA0751; mKIAA0751; Nim2; OBOE; Rab3ip2; RAB3IP3; RIM2; Rim2(+40A); Rim2(+44A); Rim2(+4A); RIMS2; Serg2; Syt3-rs
UniProt ID: (Human) Q9UQ26, (Rat) Q9JIS1, (Mouse) Q9EQZ7
Entrez Gene ID: (Human) 9699, (Rat) 116839, (Mouse) 116838
intracellular protein transport
exocytosis
adenylate cyclase-modulating G-protein coupled receptor signaling pathway
synaptic vesicle docking
synaptic vesicle priming
calcium ion regulated exocytosis
regulation of exocytosis
insulin secretion
cell differentiation
regulation of membrane potential
maintenance of presynaptic active zone structure
calcium ion-regulated exocytosis of neurotransmitter
spontaneous neurotransmitter secretion
positive regulation of inhibitory postsynaptic potential
positive regulation of dendrite extension
regulation of synaptic vesicle exocytosis
positive regulation of excitatory postsynaptic potential
positive regulation of gene expression
cAMP-mediated signaling
transport
neurotransmitter transport
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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