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Invitrogen
RIM2 Polyclonal Antibody
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Product Details
PA5-84724
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant protein corresponding to Human RIMS2. Recombinant protein control fragment (Product #RP-107501).
Conjugate
Form
Liquid
Concentration
0.2 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.2, with 40% glycerol
Contains
0.02% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Immunogen sequence: MDIEERNRQM KINKYKQVAG SDPRLEQDYH SKYRSGWDPH RGADNVSTKS S
Highest antigen sequence indentity to the following orthologs: Rat - 96%, Mouse - 96%.
Target Information
Rab3-interacting molecules (RIMs) are synaptic proteins necessary for neuronal transmission and plasticity. Rim1 and Rim2 proteins are expressed in overlapping but distinct patterns throughout the brain. While the ablation of either gene was not lethal in mice, the deletion of both resulted in postnatal mortality. This lethality is due to a defect in neurotransmitter release; synapses without RIM proteins can still release neurotransmitters but are unable to do so in response to normal Ca2+ triggers. Like Rim1, Rim2 is thought to be an effector protein for Rab3, binding to Rab3 on synaptic vesicles in a GTP-dependent manner.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: non-small cell lung cancer RimL3a protein; non-small cell lung cancer RimL3c protein; nuclear protein; Rab-3-interacting molecule 2; Rab-3-interacting protein 3; RAB3 interacting protein 3; rab3-interacting molecule 2; Rab3-interacting protein; Regulating synaptic membrane exocytosis protein 2; RIM 2; RIM2 (CT)
Gene Aliases: KIAA0751; OBOE; RAB3IP3; RIM2; RIMS2
UniProt ID: (Human) Q86XL9
Entrez Gene ID: (Human) 9699
intracellular protein transport
positive regulation of gene expression
calcium ion regulated exocytosis
regulation of exocytosis
cAMP-mediated signaling
insulin secretion
regulation of membrane potential
calcium ion-regulated exocytosis of neurotransmitter
spontaneous neurotransmitter secretion
positive regulation of inhibitory postsynaptic potential
positive regulation of dendrite extension
positive regulation of excitatory postsynaptic potential
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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