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Invitrogen
RIOK3 Polyclonal Antibody
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FIGURE: 1 / 4
RIOK3 Antibody (PA5-103249) in IHC (P)
Immunohistochemistry analysis of RIOK3 in human gastric cancer and para-carcinoma tissue. The sample was formaldehyde fixed and a heat mediated antigen retrieval step in citrate buffer was performed. Samples were incubated with RIOK3 polyclonal antibody (Product # PA5-103249) using a dilution of 1:100 (4°C overnight) followed by HRP conjugated anti-Rabbit secondary antibody.
Product Details
PA5-103249
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
A synthesized peptide derived from human RIOK3(Accession O14730), corresponding to amino acid residues E278-W328.
Conjugate
Form
Liquid
Concentration
1 mg/mL
Amount
100 µg
Purification
Affinity chromatography
Storage buffer
PBS, pH 7.4, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Antibody detects endogenous levels of total RIOK3.
Target Information
The phosphorylation and dephosphorylation of proteins on serine and threonine residues is an essential means of regulating a broad range of cellular functions in eukaryotes, including cell division, homeostasis and apoptosis. A group of proteins that are intimately involved in this process are the serine/threonine (Ser/Thr) protein kinases. SUDD, also known as RIOK3 (RIO kinase 3), is a 519 amino acid protein that contains one protein kinase domain and belongs to the Ser/Thr protein kinase family. Expressed in a variety of tissues, SUDD catayzes the ATP-dependent phosphorylation of target proteins, thereby influencing signaling events throughout the cell. SUDD is expressed as two isoforms due to alternative splicing events.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: homolog of the Aspergillus nidulans sudD gene product; RIO kinase 3; Serine/threonine-protein kinase RIO3; sudD (suppressor of bimD6, Aspergillus nidulans) homolog; sudD homolog; sudD suppressor of Aspergillus nidulans bimD6 homolog; sudD suppressor of bimD6 homolog; sudD, suppressor of bimD6 homolog; testicular secretory protein Li 47; unnamed protein product
Gene Aliases: 1200013N13Rik; D18Ertd331e; E130306C24Rik; RIOK3; SUDD
UniProt ID: (Human) O14730, (Mouse) Q9DBU3
Entrez Gene ID: (Human) 8780, (Mouse) 66878
nucleotide binding
catalytic activity
protein serine/threonine kinase activity
protein binding
ATP binding
kinase activity
transferase activity
metal ion binding
caspase binding
protein serine kinase activity
transferase activity, transferring phosphorus-containing groups
non-receptor serine/threonine protein kinase
protein modifying enzyme
immune system process
chromosome segregation
maturation of SSU-rRNA
negative regulation of protein complex assembly
positive regulation of interferon-beta production
negative regulation of MDA-5 signaling pathway
ribosome biogenesis
negative regulation of I-kappaB kinase/NF-kappaB signaling
innate immune response
positive regulation of innate immune response
defense response to virus
cellular response to dsRNA
cellular response to virus
cellular response to dsDNA
protein phosphorylation
biological_process
phosphorylation
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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