PA5-29223 targets RIP in IF and WB applications and shows reactivity with Human samples.
The PA5-29223 immunogen is recombinant protein fragment corresponding to a region within amino acids 165 and 402 of Human RIP.
Store product as a concentrated solution. Centrifuge briefly prior to opening the vial. For short-term storage (1-2 weeks), product can be stored at 4°C. For long-term storage, aliquot and store product at -20° C or below, avioiding multiple freeze-thaw cycles.
Essential adapter molecule for the activation of NF-kappa-B. Following different upstream signals (binding of inflammatory cytokines, stimulation of pathogen recognition receptors, or DNA damage), particular RIPK1-containing complexes are formed, initiating a limited number of cellular responses. Upon TNFA stimulation RIPK1 is recruited to a TRADD-TRAF complex initiated by TNFR1 trimerization. There, it is ubiquitinated via 'Lys-63'-link chains, inducing its association with the IKK complex, and its activation through NEMO binding of polyubiquitin chains.
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Protein Aliases: Cell death protein RIP; receptor (TNFRSF)-interacting serine-threonine kinase 1; receptor interacting protein; Receptor-interacting protein 1; receptor-interacting protein kinase 1; Receptor-interacting serine/threonine-protein kinase 1; RIP; RIP-1; RIP1; serine/threonine-protein kinase RIP
Gene Aliases: RIP; RIP-1; RIP1; RIPK1
UniProt ID: (Human) Q13546
Entrez Gene ID: (Human) 8737