Search
Proteintech
RIP3 Polyclonal Antibody
{{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.promotions']}}
{{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.viewpromo']}}
{{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.promocode']}}: {{promo.promoCode}} {{promo.promoTitle}} {{promo.promoDescription}}. {{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.learnmore']}}
Additional Information:
{{banner.description}}
Product Details
17563-1-AP
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse
Published species
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
RIP3 Fusion Protein Ag11759 (1-289 aa encoded by BC062584)
Conjugate
Form
Liquid
Concentration
0.17 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Wet ice (domestic); Dry ice (international)
Product Specific Information
Immunogen sequence: MSCVKLWPS GAPAPLVSIE ELENQELVGK GGFGTVFRAQ HRKWGYDVAV KIVNSKAISR EVKAMASLDN EFVLRLEGVI EKVNWDQDPK PALVTKFMEN GSLSGLLQSQ CPRPWPLLCR LLKEVVLGMF YLHDQNPVLL HRDLKPSNVL LDPELHVKLA DFGLSTFQGG SQSGTGSGEP GGTLGYLAPE LFVNVNRKAS TASDVYSFGI LMWAVLAGRE VELPTEPSLV YEAVCNRQNR PSLAELPQAG PETPGLEGLK ELMQLCWSSE PKDRPSFQEC LPKTDEVFQM (1-289 aa encoded by BC062584)
Target Information
RIPK3 is a member of the receptor-interacting protein (RIP) family of serine/threonine protein kinases, which contains a C-terminal domain unique from other RIP family members. RIPK3 is predominantly localized to the cytoplasm, and specifically, are colocalized in the mitochondrion which can undergo nucleocytoplasmic shuttling dependent on novel nuclear localization and export signals. RIPK3 is a component of the tumor necrosis factor (TNF) receptor-I signaling complex, and can induce apoptosis and weakly activate the NF-kappaB transcription factor and caspase-8 prevents RIPK3-dependent necrosis without inducing apoptosis by functioning in a proteolytically active complex with CFLAR and that this complex is required for the protective function.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: mRIP3; receptor interacting protein 3; Receptor-interacting protein 3; Receptor-interacting serine/threonine-protein kinase 3; RIP-3; RIP-like protein kinase 3; Ser/Thr kinase; unnamed protein product
Gene Aliases: 2610528K09Rik; AW107945; RIP3; RIPK3
UniProt ID: (Human) Q9Y572, (Mouse) Q9QZL0
Entrez Gene ID: (Human) 11035, (Mouse) 56532
nucleotide binding
transcription coactivator activity
protein kinase activity
protein serine/threonine kinase activity
protein binding
ATP binding
kinase activity
transferase activity
identical protein binding
macromolecular complex binding
protein serine kinase activity
NF-kappaB-inducing kinase activity
transferase activity, transferring phosphorus-containing groups
protein complex binding
non-receptor serine/threonine protein kinase
regulation of T cell mediated cytotoxicity
regulation of adaptive immune response
apoptotic process
signal transduction
positive regulation of metabolic process
regulation of gene expression
programmed cell death
activation of protein kinase activity
regulation of interferon-gamma production
T cell differentiation in thymus
protein modification process
NIK/NF-kappaB signaling
regulation of apoptotic process
T cell homeostasis
positive regulation of transcription, DNA-templated
regulation of activated T cell proliferation
lymph node development
spleen development
thymus development
positive regulation of NF-kappaB transcription factor activity
defense response to virus
positive regulation of necroptotic process
regulation of activation-induced cell death of T cells
necroptotic process
cellular response to hydrogen peroxide
reactive oxygen species metabolic process
apoptotic signaling pathway
programmed necrotic cell death
necroptotic signaling pathway
execution phase of necroptosis
amyloid fibril formation
regulation of reactive oxygen species metabolic process
positive regulation of reactive oxygen species metabolic process
regulation of CD8-positive, alpha-beta cytotoxic T cell extravasation
positive regulation of intrinsic apoptotic signaling pathway
protein phosphorylation
I-kappaB kinase/NF-kappaB signaling
positive regulation of phosphatase activity
viral process
phosphorylation
signal transduction by protein phosphorylation
protein autophosphorylation
protein homooligomerization
protein heterooligomerization
positive regulation of transferase activity
positive regulation of ligase activity
positive regulation of oxidoreductase activity
positive regulation of protein deacetylation
Disclaimer
Clicking the images or links will redirect you to a website hosted by BenchSci that provides third-party scientific content. Neither the content nor the BenchSci technology and processes for selection have been evaluated by us; we are providing them as-is and without warranty of any kind, including for use or application of the Thermo Fisher Scientific products presented.
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
Learn more
We're here to help
Get expert recommendations for common problems or connect directly with an on staff expert for technical assistance related to applications, equipment and general product use.
Contact tech support