Proteintech

RIP3 Polyclonal Antibody

RIP3 Antibody in Immunohistochemistry (Paraffin) (IHC (P))

FIGURE: 1 / 9

RIP3 Antibody (17563-1-AP) in IHC (P)

Immunohistochemistry of paraffin-embedded human pancreas tissue slide using 17563-1-AP ( RIP3 antibody at dilution of 1:200 (under 40x lens).

RIP3 Antibody in Immunoprecipitation (IP)

Product Image Gallery

Product Details

17563-1-AP

Applications

Tested Dilution

Publications

Western Blot (WB)

1:200-1:1,000

View 81 publications 81 publications

Immunohistochemistry (IHC)

View 9 publications 9 publications

Immunohistochemistry (Paraffin) (IHC (P))

1:100-1:400

Immunocytochemistry (ICC/IF)

View 11 publications 11 publications

Immunoprecipitation (IP)

0.5-4.0 µg

View 8 publications 8 publications

Not applicable (N/A)

View 2 publications 2 publications

Product Specifications

Species Reactivity

Human, Mouse

Published species

Human, Mouse, Rat

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

RIP3 Fusion Protein Ag11759 (1-289 aa encoded by BC062584)

View immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.17 mg/mL

Purification

Antigen affinity chromatography

Storage buffer

PBS, pH 7.3, with 50% glycerol

Contains

0.02% sodium azide

Storage conditions

-20°C

Shipping conditions

Wet ice (domestic); Dry ice (international)

Product Specific Information

Immunogen sequence: MSCVKLWPS GAPAPLVSIE ELENQELVGK GGFGTVFRAQ HRKWGYDVAV KIVNSKAISR EVKAMASLDN EFVLRLEGVI EKVNWDQDPK PALVTKFMEN GSLSGLLQSQ CPRPWPLLCR LLKEVVLGMF YLHDQNPVLL HRDLKPSNVL LDPELHVKLA DFGLSTFQGG SQSGTGSGEP GGTLGYLAPE LFVNVNRKAS TASDVYSFGI LMWAVLAGRE VELPTEPSLV YEAVCNRQNR PSLAELPQAG PETPGLEGLK ELMQLCWSSE PKDRPSFQEC LPKTDEVFQM (1-289 aa encoded by BC062584)

Target Information

RIPK3 is a member of the receptor-interacting protein (RIP) family of serine/threonine protein kinases, which contains a C-terminal domain unique from other RIP family members. RIPK3 is predominantly localized to the cytoplasm, and specifically, are colocalized in the mitochondrion which can undergo nucleocytoplasmic shuttling dependent on novel nuclear localization and export signals. RIPK3 is a component of the tumor necrosis factor (TNF) receptor-I signaling complex, and can induce apoptosis and weakly activate the NF-kappaB transcription factor and caspase-8 prevents RIPK3-dependent necrosis without inducing apoptosis by functioning in a proteolytically active complex with CFLAR and that this complex is required for the protective function.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

Product References

A Mitochondrion-Targeting Protein (B2) Primes ROS/Nrf2-Mediated Stress Signals, Triggering Apoptosis and Necroptosis in Lung Cancer.

Biomedicines

Chiu HW,Hung SW,Chiu CF,Hong JR

Wed Jan 11 00:00:00 UTC 2023

Effect of doramectin on programmed cell death pathway in glioma cells.

Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico

Du S,Liang H,Zhou L,Chen C,Sun R,Zhang J,Meng X,Gao A

Sun Oct 01 00:00:00 UTC 2023

Protective Effect of a Novel RIPK1 Inhibitor, Compound 4-155, in Systemic Inflammatory Response Syndrome and Sepsis.

Inflammation

Ling ZY,Lv QZ,Li J,Lu RY,Chen LL,Xu WH,Wang Y,Zhuang CL

Sun Oct 01 00:00:00 UTC 2023

N-acetyl-L-cysteine alleviated the oxidative stress-induced inflammation and necroptosis caused by excessive NiCl₂ in primary spleen lymphocytes.

Frontiers in immunology

Zhang X,Xu L,Ma W,Shi B,Liu Q,Song Y,Fang C,Liu P,Qiao S,Cai J,Zhang Z

Tue Apr 25 00:00:00 UTC 2023

Thymol Ameliorates Aspergillus fumigatus Keratitis by Downregulating the TLR4/ MyD88/ NF-kB/ IL-1β Signal Expression and Reducing Necroptosis and Pyroptosis.

Journal of microbiology and biotechnology

Wang L,Yan H,Chen X,Han L,Liu G,Yang H,Lu D,Liu W,Che C

Sat Jan 28 00:00:00 UTC 2023

Cisatracurium besylate rescues Mycobacterium Tuberculosis-infected macrophages from necroptosis and enhances the bactericidal effect of isoniazid.

International immunopharmacology

Wen Q,Zhang J,Zhang Z,Chen L,Liu H,Han Z,Chen Y,Wang K,Liu J,Sai N,Zhou X,Zhou C,Hu S,Ma L

Sat Jul 01 00:00:00 UTC 2023

Cisatracurium besylate rescues Mycobacterium Tuberculosis-infected macrophages from necroptosis and enhances the bactericidal effect of isoniazid.

International immunopharmacology

Wen Q,Zhang J,Zhang Z,Chen L,Liu H,Han Z,Chen Y,Wang K,Liu J,Sai N,Zhou X,Zhou C,Hu S,Ma L

Sat Jul 01 00:00:00 UTC 2023

Deletion of Bak1 alleviates microglial necroptosis and neuroinflammation after experimental subarachnoid hemorrhage.

Journal of neurochemistry

Qiu X,Tao Q,Zhang L,Kuang C,Xie Y,Zhang L,Yin S,Peng J,Jiang Y

Wed Mar 01 00:00:00 UTC 2023

Lactoferrin attenuated urban particulate matter-induced nephrotoxicity by regulating the CSF2/CENPE axis.

Environmental pollution (Barking, Essex : 1987)

Liu WC,Chiu HW,Chou CL,Chiu YJ,Lee YH

Wed Feb 01 00:00:00 UTC 2023

Role of SESTRIN2/AMPK/ULK1 pathway activation and lysosomes dysfunction in NaAsO₂-induced liver injury under oxidative stress.

Ecotoxicology and environmental safety

Bi D,Zheng D,Shi M,Hu Q,Wang H,Zhi H,Lou D,Zhang A,Hu Y

Sat Apr 01 00:00:00 UTC 2023

Role of SESTRIN2/AMPK/ULK1 pathway activation and lysosomes dysfunction in NaAsO₂-induced liver injury under oxidative stress.

Ecotoxicology and environmental safety

Bi D,Zheng D,Shi M,Hu Q,Wang H,Zhi H,Lou D,Zhang A,Hu Y

Sat Apr 01 00:00:00 UTC 2023

Polysaccharide from Strongylocentrotus nudus eggs regulates intestinal epithelial autophagy through CD36/PI3K-Akt pathway to ameliorate inflammatory bowel disease.

International journal of biological macromolecules

Zhou M,Zhi J,Zhi J,Xiong Z,Wu F,Lu Y,Hu Q

Mon Jul 31 00:00:00 UTC 2023

p53 Activates the Lipoxygenase Activity of ALOX15B via Inhibiting SLC7A11 to Induce Ferroptosis in Bladder Cancer Cells.

Laboratory investigation; a journal of technical methods and pathology

Li X,Xiong W,Wang Y,Li Y,Cheng X,Liu W

Mon May 01 00:00:00 UTC 2023

Identification of necroptosis-related gene TRAF5 as potential target of diagnosing atherosclerosis and assessing its stability.

BMC medical genomics

Peng Z,Wang K,Wang S,Wu R,Yao C

Sat Jun 17 00:00:00 UTC 2023

Liraglutide Attenuates Myocardial Ischemia/Reperfusion Injury Through the Inhibition of Necroptosis by Activating GLP-1R/PI3K/Akt Pathway.

Cardiovascular toxicology

Zhou G,Wu H,Yang J,Ye M,Liu D,Li Y,Zhang D,Zhang J,Yang Q,Liu Y

Sat Apr 01 00:00:00 UTC 2023

Repurposing of the FGFR inhibitor AZD4547 as a potent inhibitor of necroptosis by selectively targeting RIPK1.

Acta pharmacologica Sinica

Wang ZW,Zou FM,Wang AL,Yang J,Jin R,Wang BL,Shen LJ,Qi S,Liu J,Liu J,Wang WC,Liu QS

Sat Apr 01 00:00:00 UTC 2023

Repurposing of the FGFR inhibitor AZD4547 as a potent inhibitor of necroptosis by selectively targeting RIPK1.

Acta pharmacologica Sinica

Wang ZW,Zou FM,Wang AL,Yang J,Jin R,Wang BL,Shen LJ,Qi S,Liu J,Liu J,Wang WC,Liu QS

Sat Apr 01 00:00:00 UTC 2023

Inhibition of TRADD ameliorates chondrocyte necroptosis and osteoarthritis by blocking RIPK1-TAK1 pathway and restoring autophagy.

Cell death discovery

Sun K,Guo Z,Zhang J,Hou L,Liang S,Lu F,Wang G,Xu J,Zhang X,Guo F,Zhu W

Fri Mar 31 00:00:00 UTC 2023

Porphyromonas gingivalis lipopolysaccharide induced RIPK3/MLKL-mediated necroptosis of oral epithelial cells and the further regulation in macrophage activation.

Journal of oral microbiology

Geng F,Liu J,Yin C,Zhang S,Pan Y,Sun H

Tue Mar 08 00:00:00 UTC 2022

Protective effect of inhibiting necroptosis on gentamicin-induced nephrotoxicity.

FASEB journal : official publication of the Federation of American Societies for Experimental Biology

Hu BF,Gong Q,Chen SQ,Yue L,Ma WX,Wang F,Feng XW,Wang JN,Li C,Liu MM,Wang XF,Meng XM,Li J,Wen JG

Thu Sep 01 00:00:00 UTC 2022

Developmental exposure to chlorpyrifos causes neuroinflammation via necroptosis in mouse hippocampus and human microglial cell line.

Environmental pollution (Barking, Essex : 1987)

Tu Y,Yang Y,Wang Y,Wu N,Tao J,Yang G,You M

Thu Dec 01 00:00:00 UTC 2022

Ameliorative effects of epigallocatechin-3-gallate nanoparticles on 2,4-dinitrochlorobenzene induced atopic dermatitis: A potential mechanism of inflammation-related necroptosis.

Frontiers in nutrition

Han M,Wang X,Wang J,Lang D,Xia X,Jia Y,Chen Y

Sat Aug 27 00:00:00 UTC 2022

Study of the synergistic effect of singlet oxygen with other plasma-generated ROS in fungi inactivation during water disinfection.

The Science of the total environment

Xu H,Fang C,Shao C,Li L,Huang Q

Sat Sep 10 00:00:00 UTC 2022

New insights of necroptosis and immune infiltration in sepsis-induced myocardial dysfunction from bioinformatics analysis through RNA-seq in mice.

Frontiers in cellular and infection microbiology

Du Y,Zhong Y,Ding R,Wang X,Xia F,Zhang Q,Peng Q

Tue Jan 10 00:00:00 UTC 2023

Modification of lysine deacetylation regulates curcumol-induced necroptosis through autophagy in hepatic stellate cells.

Phytotherapy research : PTR

Sun S,Li Z,Huan S,Kai J,Xia S,Su Y,Ji S,Chen A,Wang S,Xu X,Shao J,Zhang F,Zhang B,Zhang Z,Zheng S

Wed Jun 01 00:00:00 UTC 2022

Modification of lysine deacetylation regulates curcumol-induced necroptosis through autophagy in hepatic stellate cells.

Phytotherapy research : PTR

Sun S,Li Z,Huan S,Kai J,Xia S,Su Y,Ji S,Chen A,Wang S,Xu X,Shao J,Zhang F,Zhang B,Zhang Z,Zheng S

Wed Jun 01 00:00:00 UTC 2022

Curcumol alleviates liver fibrosis by inducing endoplasmic reticulum stress-mediated necroptosis of hepatic stellate cells through Sirt1/NICD pathway.

PeerJ

Sun S,Huan S,Li Z,Yao Y,Su Y,Xia S,Wang S,Xu X,Shao J,Zhang Z,Zhang F,Fu J,Zheng S

Thu Jan 12 00:00:00 UTC 2023

Curcumol alleviates liver fibrosis by inducing endoplasmic reticulum stress-mediated necroptosis of hepatic stellate cells through Sirt1/NICD pathway.

PeerJ

Sun S,Huan S,Li Z,Yao Y,Su Y,Xia S,Wang S,Xu X,Shao J,Zhang Z,Zhang F,Fu J,Zheng S

Thu Jan 12 00:00:00 UTC 2023

Curcumol alleviates liver fibrosis by inducing endoplasmic reticulum stress-mediated necroptosis of hepatic stellate cells through Sirt1/NICD pathway.

PeerJ

Sun S,Huan S,Li Z,Yao Y,Su Y,Xia S,Wang S,Xu X,Shao J,Zhang Z,Zhang F,Fu J,Zheng S

Thu Jan 12 00:00:00 UTC 2023

Curcumol alleviates liver fibrosis by inducing endoplasmic reticulum stress-mediated necroptosis of hepatic stellate cells through Sirt1/NICD pathway.

PeerJ

Sun S,Huan S,Li Z,Yao Y,Su Y,Xia S,Wang S,Xu X,Shao J,Zhang Z,Zhang F,Fu J,Zheng S

Thu Jan 12 00:00:00 UTC 2023

Thioredoxin reductase 3 suppression promotes colitis and carcinogenesis via activating pyroptosis and necrosis.

Cellular and molecular life sciences : CMLS

Liu Q,Du P,Zhu Y,Zhang X,Cai J,Zhang Z

Sun Jan 30 00:00:00 UTC 2022

Enhancing Tumor Therapy of Fe(III)-Shikonin Supramolecular Nanomedicine via Triple Ferroptosis Amplification.

ACS applied materials & interfaces

Feng W,Shi W,Wang Z,Cui Y,Shao X,Liu S,Rong L,Liu Y,Zhang H

Wed Aug 24 00:00:00 UTC 2022

Protective Effect of MFG-E8 on Necroptosis-Induced Intestinal Inflammation and Enteroendocrine Cell Function in Diabetes.

Nutrients

Hua X,Li B,Yu F,Zhao W,Tan Y,Li X,Fu C,Yu X,Gao H,Cheng M

Sat Jan 29 00:00:00 UTC 2022

Suppression of RIP1 activity via S415 dephosphorylation ameliorates obesity-related hepatic insulin resistance.

Obesity (Silver Spring, Md.)

Wang Y,Xiong J,Yuan Y,Peng C,Wu P,Wang Y,Lu J,Yin Y,Xu J,Chen S,Liu J

Tue Mar 01 00:00:00 UTC 2022

Selenium Deficiency Induces Apoptosis and Necroptosis Through ROS/MAPK Signal in Human Uterine Smooth Muscle Cells.

Biological trace element research

Wang Y,Li X,Yao Y,Zhao X,Shi X,Cai Y

Fri Jul 01 00:00:00 UTC 2022

Salmonella pSLT-encoded effector SpvB promotes RIPK3-dependent necroptosis in intestinal epithelial cells.

Cell death discovery

Dong K,Zhu Y,Deng Q,Sun L,Yang S,Huang K,Cao Y,Li Y,Wu S,Huang R

Wed Feb 02 00:00:00 UTC 2022

Salmonella pSLT-encoded effector SpvB promotes RIPK3-dependent necroptosis in intestinal epithelial cells.

Cell death discovery

Dong K,Zhu Y,Deng Q,Sun L,Yang S,Huang K,Cao Y,Li Y,Wu S,Huang R

Wed Feb 02 00:00:00 UTC 2022

A novel necroptosis-related gene index for predicting prognosis and a cold tumor immune microenvironment in stomach adenocarcinoma.

Frontiers in immunology

Khan M,Lin J,Wang B,Chen C,Huang Z,Tian Y,Yuan Y,Bu J

Mon Nov 21 00:00:00 UTC 2022

Necrosulfonamide Alleviates Acute Brain Injury of Intracerebral Hemorrhage via Inhibiting Inflammation and Necroptosis.

Frontiers in molecular neuroscience

Zhang X,Zhang Y,Wang F,Liu Y,Yong VW,Xue M

Sat Jul 16 00:00:00 UTC 2022

Mesenchymal Stem Cells-Derived Exosomes Ameliorate Ischemia/Reperfusion Induced Acute Kidney Injury in a Porcine Model.

Frontiers in cell and developmental biology

Huang J,Cao H,Cui B,Ma X,Gao L,Yu C,Shen F,Yang X,Liu N,Qiu A,Cai G,Zhuang S

Fri Nov 17 00:00:00 UTC 2023

Biotransformation of graphene oxide within lung fluids could intensify its synergistic biotoxicity effect with cadmium by inhibiting cellular efflux of cadmium.

Environmental pollution (Barking, Essex : 1987)

Zhu J,Liu L,Ma J,Fu Q,Zheng Z,Du E,Xu Y,Zhang Z

Mon Aug 01 00:00:00 UTC 2022

Novel pharmacological inhibition of JMJD3 improves necrotizing enterocolitis by attenuating the inflammatory response and ameliorating intestinal injury.

Biochemical pharmacology

Ma S,Xu L,Chen L,Sun X,Hu F,Gong Y,Yang R,Li J,Wang Q,Huang S,Zhou H,Wang J

Thu Sep 01 00:00:00 UTC 2022

Novel pharmacological inhibition of JMJD3 improves necrotizing enterocolitis by attenuating the inflammatory response and ameliorating intestinal injury.

Biochemical pharmacology

Ma S,Xu L,Chen L,Sun X,Hu F,Gong Y,Yang R,Li J,Wang Q,Huang S,Zhou H,Wang J

Thu Sep 01 00:00:00 UTC 2022

Central nervous system stimulants promote nerve cell death under continuous hypoxia.

Human cell

Ikeda-Murakami K,Ikeda T,Watanabe M,Tani N,Ishikawa T

Thu Sep 01 00:00:00 UTC 2022

Role of HMGB1 in TNF-α Combined with Z-VAD-fmk-Induced L929 Cells Necroptosis.

Biochemical genetics

Yu C,Lei Z,Li X,Huang LH,Li ZQ,Zhu HW,Han D,Huang H,Yu X

Fri Apr 01 00:00:00 UTC 2022

LncRNA 122049 suppresses apoptosis of renal tubular epithelial cells in ischemic AKI by targeting the miR-330-5p/ELK1 axis.

FASEB journal : official publication of the Federation of American Societies for Experimental Biology

Xiao Y,Li X,Qiu S,Wang Y,Zhang D

Fri Jul 01 00:00:00 UTC 2022

LRG-1 promotes fat graft survival through the RAB31-mediated inhibition of hypoxia-induced apoptosis.

Journal of cellular and molecular medicine

Ho CK,Zheng D,Sun J,Wen D,Wu S,Yu L,Gao Y,Zhang Y,Li Q

Wed Jun 01 00:00:00 UTC 2022

Paeoniflorin directly binds to TNFR1 to regulate podocyte necroptosis in diabetic kidney disease.

Frontiers in pharmacology

Wang X,Liu XQ,Jiang L,Huang YB,Zeng HX,Zhu QJ,Qi XM,Wu YG

Sat Sep 24 00:00:00 UTC 2022

Caspase-8 is involved in pyroptosis, necroptosis and the maturation and release of IL-1β in Aspergillus fumigatus keratitis.

International immunopharmacology

Wang L,Yan H,Chen X,Lee J,Sun J,Liu G,Yang H,Lu D,Liu W,Che C

Thu Dec 01 00:00:00 UTC 2022

The role of KIAA1191 in the necroptotic pathway of multiple myeloma.

Annals of hematology

Xu Z,Sun Y,Jiang J,Liu P

Tue Feb 01 00:00:00 UTC 2022

Blue Light Induces RPE Cell Necroptosis, Which Can Be Inhibited by Minocycline.

Frontiers in medicine

Song W,Zhu R,Gao W,Xing C,Yang L

Mon May 16 00:00:00 UTC 2022

RIPK3-Dependent Necroptosis Activates MCP-1-Mediated Inflammation in Mice after Intracerebral Hemorrhage.

Journal of stroke and cerebrovascular diseases : the official journal of National Stroke Association

Huang S,Hu W,Rao D,Wu X,Bai Q,Wang J,Chu Z,Xu Y

Sat Jan 01 00:00:00 UTC 2022

RIPK3-Dependent Necroptosis Activates MCP-1-Mediated Inflammation in Mice after Intracerebral Hemorrhage.

Journal of stroke and cerebrovascular diseases : the official journal of National Stroke Association

Huang S,Hu W,Rao D,Wu X,Bai Q,Wang J,Chu Z,Xu Y

Sat Jan 01 00:00:00 UTC 2022

RIPK3-Dependent Necroptosis Activates MCP-1-Mediated Inflammation in Mice after Intracerebral Hemorrhage.

Journal of stroke and cerebrovascular diseases : the official journal of National Stroke Association

Huang S,Hu W,Rao D,Wu X,Bai Q,Wang J,Chu Z,Xu Y

Sat Jan 01 00:00:00 UTC 2022

Sperm-Associated Antigen 9 Promotes Influenza A Virus-Induced Cell Death via the c-Jun N-Terminal Kinase Signaling Pathway.

mBio

Gui R,Zheng H,Ma L,Liu R,Lin X,Ke X,Ye C,Jian X,Chen Q

Tue Jun 28 00:00:00 UTC 2022

Targeting Inhibition of Accumulation and Function of Myeloid-Derived Suppressor Cells by Artemisinin via PI3K/AKT, mTOR, and MAPK Pathways Enhances Anti-PD-L1 Immunotherapy in Melanoma and Liver Tumors.

Journal of immunology research

Zhang M,Wang L,Liu W,Wang T,De Sanctis F,Zhu L,Zhang G,Cheng J,Cao Q,Zhou J,Tagliabue A,Bronte V,Yan D,Wan X,Yu G

Wed Jul 06 00:00:00 UTC 2022

Tea polyphenols alleviates acetochlor-induced apoptosis and necroptosis via ROS/MAPK/NF-κB signaling in Ctenopharyngodon idellus kidney cells.

Aquatic toxicology (Amsterdam, Netherlands)

Zhao X,Shi X,Liu Q,Li X

Sun May 01 00:00:00 UTC 2022

Expression of the ACE2 Virus Entry Protein in the Nervus Terminalis Reveals the Potential for an Alternative Route to Brain Infection in COVID-19.

Frontiers in cellular neuroscience

Bilinska K,von Bartheld CS,Butowt R

Thu Nov 02 00:00:00 UTC 2023

Traditional herbal formula Wu-Mei-Wan alleviates TNBS-induced colitis in mice by inhibiting necroptosis through increasing RIPK3 O-GlcNAcylation.

Chinese medicine

Wu F,Shao Q,Cheng Z,Xiong X,Fang K,Zhao Y,Dong R,Xu L,Lu F,Chen G

Mon Aug 16 00:00:00 UTC 2021

RIPK3-Dependent Necroptosis Is Induced and Restricts Viral Replication in Human Astrocytes Infected With Zika Virus.

Frontiers in cellular and infection microbiology

Wen C,Yu Y,Gao C,Qi X,Cardona CJ,Xing Z

Mon Jul 05 00:00:00 UTC 2021

Ligand-based substituent-anchoring design of selective receptor-interacting protein kinase 1 necroptosis inhibitors for ulcerative colitis therapy.

Acta pharmaceutica Sinica. B

Zhu J,Xin M,Xu C,He Y,Zhang W,Wang Z,Zhuang C

Fri Oct 01 00:00:00 UTC 2021

CB1R Promotes Chronic Alcohol-Induced Neuronal Necroptosis in Mice Prefrontal Cortex.

Alcohol and alcoholism (Oxford, Oxfordshire)

Ye L,Li S,Liu X,Zhang D,Li L,Jiang Y

Wed Feb 24 00:00:00 UTC 2021

Yi-Qi-Jian-Pi Formula Suppresses RIPK1/RIPK3-Complex-Dependent Necroptosis of Hepatocytes Through ROS Signaling and Attenuates Liver Injury in Vivo and in Vitro.

Frontiers in pharmacology

Wang F,Tang L,Liang B,Jin C,Gao L,Li Y,Li Z,Shao J,Zhang Z,Tan S,Zhang F,Zheng S

Thu May 13 00:00:00 UTC 2021

Yi-Qi-Jian-Pi Formula Suppresses RIPK1/RIPK3-Complex-Dependent Necroptosis of Hepatocytes Through ROS Signaling and Attenuates Liver Injury in Vivo and in Vitro.

Frontiers in pharmacology

Wang F,Tang L,Liang B,Jin C,Gao L,Li Y,Li Z,Shao J,Zhang Z,Tan S,Zhang F,Zheng S

Thu May 13 00:00:00 UTC 2021

Yi-Qi-Jian-Pi Formula Suppresses RIPK1/RIPK3-Complex-Dependent Necroptosis of Hepatocytes Through ROS Signaling and Attenuates Liver Injury in Vivo and in Vitro.

Frontiers in pharmacology

Wang F,Tang L,Liang B,Jin C,Gao L,Li Y,Li Z,Shao J,Zhang Z,Tan S,Zhang F,Zheng S

Thu May 13 00:00:00 UTC 2021

Yi-Qi-Jian-Pi Formula Suppresses RIPK1/RIPK3-Complex-Dependent Necroptosis of Hepatocytes Through ROS Signaling and Attenuates Liver Injury in Vivo and in Vitro.

Frontiers in pharmacology

Wang F,Tang L,Liang B,Jin C,Gao L,Li Y,Li Z,Shao J,Zhang Z,Tan S,Zhang F,Zheng S

Thu May 13 00:00:00 UTC 2021

Yi-Qi-Jian-Pi Formula Suppresses RIPK1/RIPK3-Complex-Dependent Necroptosis of Hepatocytes Through ROS Signaling and Attenuates Liver Injury in Vivo and in Vitro.

Frontiers in pharmacology

Wang F,Tang L,Liang B,Jin C,Gao L,Li Y,Li Z,Shao J,Zhang Z,Tan S,Zhang F,Zheng S

Thu May 13 00:00:00 UTC 2021

Yi-Qi-Jian-Pi Formula Suppresses RIPK1/RIPK3-Complex-Dependent Necroptosis of Hepatocytes Through ROS Signaling and Attenuates Liver Injury in Vivo and in Vitro.

Frontiers in pharmacology

Wang F,Tang L,Liang B,Jin C,Gao L,Li Y,Li Z,Shao J,Zhang Z,Tan S,Zhang F,Zheng S

Thu May 13 00:00:00 UTC 2021

Deficiency of NEAT1 prevented MPP⁺-induced inflammatory response, oxidative stress and apoptosis in dopaminergic SK-N-SH neuroblastoma cells via miR-1277-5p/ARHGAP26 axis.

Brain research

Zhou S,Zhang D,Guo J,Chen Z,Chen Y,Zhang J

Fri Jan 01 00:00:00 UTC 2021

Small-molecule inhibition of APE1 induces apoptosis, pyroptosis, and necroptosis in non-small cell lung cancer.

Cell death & disease

Long K,Gu L,Li L,Zhang Z,Li E,Zhang Y,He L,Pan F,Guo Z,Hu Z

Tue May 18 00:00:00 UTC 2021

Metformin attenuates hypothalamic inflammation via downregulation of RIPK1-independent microglial necroptosis in diet-induced obese mice.

Cell death discovery

Li X,Cai Y,Luo J,Ding J,Yao G,Xiao X,Tang Y,Liang Z

Mon Nov 08 00:00:00 UTC 2021

ERRFI1 induces apoptosis of hepatocellular carcinoma cells in response to tryptophan deficiency.

Cell death discovery

Cui M,Liu D,Xiong W,Wang Y,Mi J

Mon Oct 04 00:00:00 UTC 2021

The Performance of HepG2 and HepaRG Systems through the Glass of Acetaminophen-Induced Toxicity.

Life (Basel, Switzerland)

Lőrincz T,Deák V,Makk-Merczel K,Varga D,Hajdinák P,Szarka A

Sat Aug 21 00:00:00 UTC 2021

Cadmium exposure induces TNF-α-mediated necroptosis via FPR2/TGF-β/NF-κB pathway in swine myocardium.

Toxicology

Zhao X,Wang S,Li X,Liu H,Xu S

Thu Apr 15 00:00:00 UTC 2021

Pterocephin A, a novel Triterpenoid Saponin from Pterocephalus hookeri induced liver injury by activation of necroptosis.

Phytomedicine : international journal of phytotherapy and phytopharmacology

Wang R,Wei L,Dong Z,Meng F,Wang G,Zhou S,Lan X,Liao Z,Chen M

Sat May 01 00:00:00 UTC 2021

Intermittent hypoxia aggravates non-alcoholic fatty liver disease via RIPK3-dependent necroptosis-modulated Nrf2/NFκB signaling pathway.

Life sciences

Zhang H,Zhou L,Zhou Y,Wang L,Jiang W,Liu L,Yue S,Zheng P,Liu H

Mon Nov 15 00:00:00 UTC 2021

TNFAIP3-upregulated RIP3 exacerbates acute pancreatitis via activating NLRP3 inflammasome.

International immunopharmacology

Wang Y,Song M,Zhou P,Wang J,Zheng J,Xu H

Mon Nov 01 00:00:00 UTC 2021

SETDB1-Mediated Cell Fate Transition between 2C-Like and Pluripotent States.

Cell reports

Wu K,Liu H,Wang Y,He J,Xu S,Chen Y,Kuang J,Liu J,Guo L,Li D,Shi R,Shen L,Wang Y,Zhang X,Wang J,Pei D,Chen J

Tue Jan 07 00:00:00 UTC 2020

mtDNA-STING pathway promotes necroptosis-dependent enterocyte injury in intestinal ischemia reperfusion.

Cell death & disease

Zhang X,Wu J,Liu Q,Li X,Li S,Chen J,Hong Z,Wu X,Zhao Y,Ren J

Fri Dec 11 00:00:00 UTC 2020

Insights into mechanisms of pranoprofen-induced apoptosis and necroptosis in human corneal stromal cells.

Toxicology letters

Lin Y,Yu M,Fan T

Sun Mar 01 00:00:00 UTC 2020

Necroptosis mediated by impaired autophagy flux contributes to adverse ventricular remodeling after myocardial infarction.

Biochemical pharmacology

Zhang H,Yin Y,Liu Y,Zou G,Huang H,Qian P,Zhang G,Zhang J

Fri May 01 00:00:00 UTC 2020

Pharmacological activation of CB2 receptor protects against ethanol-induced myocardial injury related to RIP1/RIP3/MLKL-mediated necroptosis.

Molecular and cellular biochemistry

Liu X,Zhang D,Dong X,Zhu R,Ye Y,Li L,Jiang Y

Sun Nov 01 00:00:00 UTC 2020

Cryptotanshinone protects dextran sulfate sodium-induced experimental ulcerative colitis in mice by inhibiting intestinal inflammation.

Phytotherapy research : PTR

Min X,Zeng X,Zhao W,Han Z,Wang Y,Han Y,Pei L,Chen X

Thu Oct 01 00:00:00 UTC 2020

Cryptotanshinone protects dextran sulfate sodium-induced experimental ulcerative colitis in mice by inhibiting intestinal inflammation.

Phytotherapy research : PTR

Min X,Zeng X,Zhao W,Han Z,Wang Y,Han Y,Pei L,Chen X

Thu Oct 01 00:00:00 UTC 2020

Protective effect of astaxanthin against SnS₂ nanoflowers induced testes toxicity by suppressing RIPK1-RIPK3-MLKL signaling in mice.

Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association

Yuan L,Liang P,Qu Y,An T,Wang J,Deng X,Bai L,Shen P,Bai D

Sun Nov 01 00:00:00 UTC 2020

Norfloxacin induces apoptosis and necroptosis in human corneal epithelial cells.

Toxicology in vitro : an international journal published in association with BIBRA

Yang T,Fan TJ,Xu B

Sat Aug 01 00:00:00 UTC 2020

Necrostatin-1 Alleviates Bleomycin-Induced Pulmonary Fibrosis and Extracellular Matrix Expression in Interstitial Pulmonary Fibrosis.

Medical science monitor : international medical journal of experimental and clinical research

Mou F,Mou C

Wed Feb 05 00:00:00 UTC 2020

M10, a Myricetin-3-O-b-D-Lactose Sodium Salt, Prevents Ulcerative Colitis Through Inhibiting Necroptosis in Mice.

Frontiers in pharmacology

Zhou XL,Yang J,Qu XJ,Meng J,Miao RR,Cui SX

Sun Apr 17 00:00:00 UTC 2022

Raman micro-spectroscopy monitoring of cytochrome c redox state in Candida utilis during cell death under low-temperature plasma-induced oxidative stress.

The Analyst

Chen Z,Liu J,Tian L,Zhang Q,Guan Y,Chen L,Liu G,Yu HQ,Tian Y,Huang Q

Sun Jun 07 00:00:00 UTC 2020

Raman micro-spectroscopy monitoring of cytochrome c redox state in Candida utilis during cell death under low-temperature plasma-induced oxidative stress.

The Analyst

Chen Z,Liu J,Tian L,Zhang Q,Guan Y,Chen L,Liu G,Yu HQ,Tian Y,Huang Q

Sun Jun 07 00:00:00 UTC 2020

Combination of Rapamycin and MK-2206 Induced Cell Death via Autophagy and Necroptosis in MYCN-Amplified Neuroblastoma Cell Lines.

Frontiers in pharmacology

Dong Y,Gong W,Hua Z,Chen B,Zhao G,Liu Z,Thiele CJ,Li Z

Mon Sep 28 00:00:00 UTC 2020

Combination of Rapamycin and MK-2206 Induced Cell Death via Autophagy and Necroptosis in MYCN-Amplified Neuroblastoma Cell Lines.

Frontiers in pharmacology

Dong Y,Gong W,Hua Z,Chen B,Zhao G,Liu Z,Thiele CJ,Li Z

Mon Sep 28 00:00:00 UTC 2020

Protective effect of dabrafenib on renal ischemia-reperfusion injury in vivo and in vitro.

Biochemical and biophysical research communications

Liu SS,Chen YY,Wang SX,Yu Q

Wed Feb 05 00:00:00 UTC 2020

Coxsackievirus A6 Induces Necroptosis for Viral Production.

Frontiers in microbiology

Zhang S,Yu X,Meng X,Huo W,Su Y,Liu J,Liu Y,Zhang J,Wang S,Yu J

Mon Sep 28 00:00:00 UTC 2020

Coxsackievirus A6 Induces Necroptosis for Viral Production.

Frontiers in microbiology

Zhang S,Yu X,Meng X,Huo W,Su Y,Liu J,Liu Y,Zhang J,Wang S,Yu J

Mon Sep 28 00:00:00 UTC 2020

Coxsackievirus A6 Induces Necroptosis for Viral Production.

Frontiers in microbiology

Zhang S,Yu X,Meng X,Huo W,Su Y,Liu J,Liu Y,Zhang J,Wang S,Yu J

Mon Sep 28 00:00:00 UTC 2020

MUC1 downregulation promotes TNF-α-induced necroptosis in human bronchial epithelial cells via regulation of the RIPK1/RIPK3 pathway.

Journal of cellular physiology

Zhang H,Ji J,Liu Q,Xu S

Sun Sep 01 00:00:00 UTC 2019

MUC1 downregulation promotes TNF-α-induced necroptosis in human bronchial epithelial cells via regulation of the RIPK1/RIPK3 pathway.

Journal of cellular physiology

Zhang H,Ji J,Liu Q,Xu S

Sun Sep 01 00:00:00 UTC 2019

A "Hibernating-Like" Viable State Induced by Lentiviral Vector-Mediated Pigment Epithelium-Derived Factor Overexpression in Rat Acute Ischemic Myocardium.

Human gene therapy

Yuan Y,Huang B,Miao H,Liu X,Zhang H,Qiu F,Liu Z,Zhang Y,Dong H,Zhang Z

Sat Jun 01 00:00:00 UTC 2019

Dexmedetomidine Preconditioning Protects Cardiomyocytes Against Hypoxia/Reoxygenation-Induced Necroptosis by Inhibiting HMGB1-Mediated Inflammation.

Cardiovascular drugs and therapy

Chen J,Jiang Z,Zhou X,Sun X,Cao J,Liu Y,Wang X

Fri Feb 01 00:00:00 UTC 2019

Quetiapine induces myocardial necroptotic cell death through bidirectional regulation of cannabinoid receptors.

Toxicology letters

Li X,Peng Z,Zhou Y,Wang J,Lin X,Dong X,Liu X,Jiang J,Jiang Y,Li L

Tue Oct 01 00:00:00 UTC 2019

Quetiapine induces myocardial necroptotic cell death through bidirectional regulation of cannabinoid receptors.

Toxicology letters

Li X,Peng Z,Zhou Y,Wang J,Lin X,Dong X,Liu X,Jiang J,Jiang Y,Li L

Tue Oct 01 00:00:00 UTC 2019

Necroptosis and Apoptosis Contribute to Cisplatin and Aminoglycoside Ototoxicity.

The Journal of neuroscience : the official journal of the Society for Neuroscience

Ruhl D,Du TT,Wagner EL,Choi JH,Li S,Reed R,Kim K,Freeman M,Hashisaki G,Lukens JR,Shin JB

Wed Apr 10 00:00:00 UTC 2019

PEDF decreases cardiomyocyte edema during oxygen‑glucose deprivation and recovery via inhibiting lactate accumulation and expression of AQP1.

International journal of molecular medicine

Huang B,Miao H,Yuan Y,Qiu F,Liu X,Liu Z,Zhang H,Zhao Q,Wang M,Dong H,Zhang Z

Wed May 01 00:00:00 UTC 2019

Evaluation of the Liver Toxicity of Pterocephalus hookeri Extract via Triggering Necrosis.

Toxins

Wang R,Dong Z,Zhang X,Mao J,Meng F,Lan X,Liao Z,Chen M

Sat Mar 02 00:00:00 UTC 2019

The role of the LncRNA-FA2H-2-MLKL pathway in atherosclerosis by regulation of autophagy flux and inflammation through mTOR-dependent signaling.

Cell death and differentiation

Guo FX,Wu Q,Li P,Zheng L,Ye S,Dai XY,Kang CM,Lu JB,Xu BM,Xu YJ,Xiao L,Lu ZF,Bai HL,Hu YW,Wang Q

Sun Sep 01 00:00:00 UTC 2019

The role of the LncRNA-FA2H-2-MLKL pathway in atherosclerosis by regulation of autophagy flux and inflammation through mTOR-dependent signaling.

Cell death and differentiation

Guo FX,Wu Q,Li P,Zheng L,Ye S,Dai XY,Kang CM,Lu JB,Xu BM,Xu YJ,Xiao L,Lu ZF,Bai HL,Hu YW,Wang Q

Sun Sep 01 00:00:00 UTC 2019

Necrostatin-1 Attenuates Renal Ischemia and Reperfusion Injury via Meditation of HIF-1α/mir-26a/TRPC6/PARP1 Signaling.

Molecular therapy. Nucleic acids