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Search Thermo Fisher Scientific
Applications | Tested Dilution | Publications |
---|---|---|
Western Blot (WB) |
1:200-1:1,000 | View 6 publications 6 publications |
Immunohistochemistry (Paraffin) (IHC (P)) |
1:100-1:400 | - |
Immunoprecipitation (IP) |
0.5-4.0 µg | - |
Product Specifications | |
---|---|
Species Reactivity |
Human, Mouse |
Published species |
Human, Mouse |
Host/Isotype |
Rabbit / IgG |
Class |
Polyclonal |
Type |
Antibody |
Immunogen |
RIP3 Fusion Protein Ag11759 (1-289 aa encoded by BC062584) |
Conjugate |
Unconjugated |
Form |
Liquid |
Concentration |
0.17 mg/mL |
Purification |
Antigen affinity chromatography |
Storage buffer |
PBS, pH 7.3, with 50% glycerol |
Contains |
0.02% sodium azide |
Storage conditions |
-20°C |
Immunogen sequence: MSCVKLWPS GAPAPLVSIE ELENQELVGK GGFGTVFRAQ HRKWGYDVAV KIVNSKAISR EVKAMASLDN EFVLRLEGVI EKVNWDQDPK PALVTKFMEN GSLSGLLQSQ CPRPWPLLCR LLKEVVLGMF YLHDQNPVLL HRDLKPSNVL LDPELHVKLA DFGLSTFQGG SQSGTGSGEP GGTLGYLAPE LFVNVNRKAS TASDVYSFGI LMWAVLAGRE VELPTEPSLV YEAVCNRQNR PSLAELPQAG PETPGLEGLK ELMQLCWSSE PKDRPSFQEC LPKTDEVFQM (1-289 aa encoded by BC062584)
RIP3 is a novel member of RIP Ser/Thr kinase family. It is a potent inducer of apoptosis and is an important component of TNFR1 signaling complex. RIP3 consists of an N-terminal RIP-like-Kinase domain and a unique, non-homologous C-terminus responsible for caspase activation and apoptosis induction. RIP3 is expressed in multiple tissues including hematopoietic cells and plays a functional role in the regulation of apoptosis and NF-kB signaling. It is recruited to the TNFR1 signaling complex in a RIP-dependant manner where it induces apoptosis by activating caspases and/or inhibiting TNFR1-induced NF-kB activation. RIP3 negatively regulates the TLR3-Trif-mediated NF-kB signaling pathway by competing with the binding of Trif to RIP1. The human RIP3 gene is localized in the chromosomal region 14q11.2.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: mRIP3; receptor interacting protein 3; Receptor-interacting protein 3; receptor-interacting serine-threonine kinase 3; Receptor-interacting serine/threonine-protein kinase 3; RIP-3; RIP-like protein kinase 3
Gene Aliases: 2610528K09Rik; AW107945; RIP3; RIPK3
UniProt ID: (Human) Q9Y572, (Mouse) Q9QZL0
Entrez Gene ID: (Human) 11035, (Mouse) 56532
Molecular Function:
non-receptor serine/threonine protein kinase
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