Search
Disclaimer
Clicking the images or links will redirect you to a website hosted by BenchSci that provides third-party scientific content. Neither the content nor the BenchSci technology and processes for selection have been evaluated by us; we are providing them as-is and without warranty of any kind, including for use or application of the Thermo Fisher Scientific products presented.
Proteintech
RIP3 Polyclonal Antibody, CoraLite® Plus 488
{{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.promotions']}}
{{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.viewpromo']}}
{{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.promocode']}}: {{promo.promoCode}} {{promo.promoTitle}} {{promo.promoDescription}}. {{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.learnmore']}}
Product Details
CL488-17563
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
RIP3 fusion protein Ag11759
Conjugate
Excitation/Emission Max
493/522 nm
Form
Liquid
Concentration
1 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.3, with 0.5% BSA, 50% glycerol
Contains
0.05% ProClin 300
Storage conditions
-20°C, store in dark
Shipping conditions
Wet ice
Product Specific Information
Immunogen sequence: MSCVKLWPS GAPAPLVSIE ELENQELVGK GGFGTVFRAQ HRKWGYDVAV KIVNSKAISR EVKAMASLDN EFVLRLEGVI EKVNWDQDPK PALVTKFMEN GSLSGLLQSQ CPRPWPLLCR LLKEVVLGMF YLHDQNPVLL HRDLKPSNVL LDPELHVKLA DFGLSTFQGG SQSGTGSGEP GGTLGYLAPE LFVNVNRKAS TASDVYSFGI LMWAVLAGRE VELPTEPSLV YEAVCNRQNR PSLAELPQAG PETPGLEGLK ELMQLCWSSE PKDRPSFQEC LPKTDEVFQM
Target Information
RIPK3 is a member of the receptor-interacting protein (RIP) family of serine/threonine protein kinases, which contains a C-terminal domain unique from other RIP family members. RIPK3 is predominantly localized to the cytoplasm, and specifically, are colocalized in the mitochondrion which can undergo nucleocytoplasmic shuttling dependent on novel nuclear localization and export signals. RIPK3 is a component of the tumor necrosis factor (TNF) receptor-I signaling complex, and can induce apoptosis and weakly activate the NF-kappaB transcription factor and caspase-8 prevents RIPK3-dependent necrosis without inducing apoptosis by functioning in a proteolytically active complex with CFLAR and that this complex is required for the protective function.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
References (0)
Have you cited this product in a publication?
Let us know so we can reference it here.
Bioinformatics
Protein Aliases: receptor interacting protein 3; Receptor-interacting protein 3; receptor-interacting serine-threonine kinase 3; Receptor-interacting serine/threonine-protein kinase 3; RIP-3; RIP-like protein kinase 3
Gene Aliases: RIP3; RIPK3
UniProt ID: (Human) Q9Y572
Entrez Gene ID: (Human) 11035
regulation of T cell mediated cytotoxicity
regulation of adaptive immune response
cellular protein modification process
signal transduction
I-kappaB kinase/NF-kappaB signaling
positive regulation of phosphatase activity
activation of protein kinase activity
regulation of interferon-gamma production
T cell differentiation in thymus
NIK/NF-kappaB signaling
T cell homeostasis
regulation of activated T cell proliferation
protein autophosphorylation
lymph node development
spleen development
thymus development
positive regulation of NF-kappaB transcription factor activity
protein homooligomerization
protein heterooligomerization
positive regulation of ligase activity
positive regulation of oxidoreductase activity
positive regulation of necroptotic process
regulation of activation-induced cell death of T cells
necroptotic process
positive regulation of protein deacetylation
apoptotic signaling pathway
amyloid fibril formation
positive regulation of reactive oxygen species metabolic process
regulation of CD8-positive, alpha-beta cytotoxic T cell extravasation
positive regulation of intrinsic apoptotic signaling pathway
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
Learn more
We're here to help
Get expert recommendations for common problems or connect directly with an on staff expert for technical assistance related to applications, equipment and general product use.
Contact tech support