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Fabgennix
RIPK3 Polyclonal Antibody, FITC
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Product Details
RIPK3-301-FITC
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Bovine,
Human,
Non-human primate,
Pig
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Synthetic peptide taken within amino acid region 461-511 on human Receptor-interacting Serine/Threonine-protein kinase 3 protein.
Conjugate
Excitation/Emission Max
498/517 nm
View spectra
Form
Liquid
Concentration
0.5-1.5 mg/mL
Purification
Affinity chromatography
Storage buffer
proprietary buffer, pH 7.4-7.8, with 0.5% BSA, 30% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C, store in dark
Shipping conditions
Ambient (domestic); Wet ice (international)
Target Information
RIPK3 is a member of the receptor-interacting protein (RIP) family of serine/threonine protein kinases, which contains a C-terminal domain unique from other RIP family members. RIPK3 is predominantly localized to the cytoplasm, and specifically, are colocalized in the mitochondrion which can undergo nucleocytoplasmic shuttling dependent on novel nuclear localization and export signals. RIPK3 is a component of the tumor necrosis factor (TNF) receptor-I signaling complex, and can induce apoptosis and weakly activate the NF-kappaB transcription factor and caspase-8 prevents RIPK3-dependent necrosis without inducing apoptosis by functioning in a proteolytically active complex with CFLAR and that this complex is required for the protective function.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: receptor interacting protein 3; Receptor-interacting protein 3; Receptor-interacting serine/threonine-protein kinase 3; RIP-3; RIP-like protein kinase 3; Ser/Thr kinase; unnamed protein product
Gene Aliases: RIP3; RIPK3
UniProt ID: (Human) Q9Y572
Entrez Gene ID: (Human) 11035, (Pig) 100153263, (Bovine) 507427
nucleotide binding
transcription coactivator activity
protein kinase activity
protein serine/threonine kinase activity
protein binding
ATP binding
kinase activity
transferase activity
identical protein binding
macromolecular complex binding
protein serine kinase activity
non-receptor serine/threonine protein kinase
regulation of T cell mediated cytotoxicity
regulation of adaptive immune response
apoptotic process
signal transduction
positive regulation of metabolic process
regulation of gene expression
programmed cell death
activation of protein kinase activity
regulation of interferon-gamma production
T cell differentiation in thymus
protein modification process
NIK/NF-kappaB signaling
regulation of apoptotic process
T cell homeostasis
positive regulation of transcription, DNA-templated
regulation of activated T cell proliferation
lymph node development
spleen development
thymus development
positive regulation of NF-kappaB transcription factor activity
defense response to virus
positive regulation of necroptotic process
regulation of activation-induced cell death of T cells
necroptotic process
cellular response to hydrogen peroxide
reactive oxygen species metabolic process
apoptotic signaling pathway
programmed necrotic cell death
necroptotic signaling pathway
execution phase of necroptosis
amyloid fibril formation
regulation of reactive oxygen species metabolic process
positive regulation of reactive oxygen species metabolic process
regulation of CD8-positive, alpha-beta cytotoxic T cell extravasation
positive regulation of intrinsic apoptotic signaling pathway
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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