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Proteintech
RLBP1 Polyclonal Antibody, CoraLite® Plus 488
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Product Details
CL488-15356
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
RLBP1 fusion protein Ag7602
Conjugate
Excitation/Emission Max
493/522 nm
Form
Liquid
Concentration
1 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.3, with 0.5% BSA, 50% glycerol
Contains
0.05% ProClin 300
Storage conditions
-20°C, store in dark
Shipping conditions
Wet ice
Product Specific Information
Immunogen sequence: MSEGVGTFR MVPEEEQELR AQLEQLTTKD HGPVFGPCSQ LPRHTLQKAK DELNEREETR EEAVRELQEM VQAQAASGEE LAVAVAERVQ EKDSGFFLRF IRARKFNVGR AYELLRGYVN FRLQYPELFD SLSPEAVRCT IEAGYPGVLS SRDKYGRVVM LFNIENWQSQ EITFDEILQA YCFILEKLLE NEETQINGFC IIENFKGFTM QQAASLRTSD LRKMVDMLQD SFPARFKAIH FIHQPWYFTT TYNVVKPFLK SKLLERVFVH GDDLSGFYQE IDENILPSDF GGTLPKYDGK AVAEQLFGPQ AQAENTAF
Target Information
Cellular retinaldehyde-binding protein (CRALBP) plays an important role in the regeneration of 11-cis-retinal for use in rod visual pigments such as opsin and rhodopsin. Once 11-cis-retinal is photoisomerized in the rod outer segment, it is converted to all-trans-retinal and further modified into all-trans-retinol. All-trans-retinol then diffuses into the retinal pigment epithelium (RPE) to be converted back to 11-cis-retinol and further oxidized into 11-cis-retinal (both by CRALBP). Genetic mutations involving CRALBP's lack of function have been linked to visual disease such as bothnia dystrophy, retinitis punctata albescens, retina pigmentosa, and Newfoundland rod-cone dystrophy. The presence of CRALBP serves as a marker for RPE and Muller glial cells of the retina.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: Cellular retinaldehyde-binding protein; cellular retinaldehyde-binding protein-1; Retinaldehyde-binding protein 1
Gene Aliases: 3110056M11Rik; CRALBP; RLBP1
UniProt ID: (Human) P12271, (Mouse) Q9Z275
Entrez Gene ID: (Human) 6017, (Mouse) 19771, (Rat) 293049
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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