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Proteintech
RLN3 Polyclonal Antibody
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Product Details
26075-1-AP
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
RLN3 Fusion Protein Ag23382 (27-142 aa encoded by BC140935)
Conjugate
Form
Liquid
Concentration
0.3 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Wet ice (domestic); Dry ice (international)
Product Specific Information
Immunogen sequence: AAPYGVRLC GREFIRAVIF TCGGSRWRRS DILAHEAMGD TFPDADADED SLAGELDEAM GSSEWLALTK SPQAFYRGRP SWQGTPVVLR GSRDVLAGLS SSCCKWGCSK SEISSLC (27-142 aa encoded by BC140935)
Target Information
Relaxin 3 is part of the Relaxin-like peptide family that plays an important neuropeptide signaling role. Relaxin 3 is a ligand for two structurally related G protein-coupled receptors, human Relaxin receptor 3 and Relaxin receptor 4. The greatest levels of Relaxin 3 expression occur in the brain, specifically in the pons/medulla, with highest levels in the pars ventromedialis of the dorsal tegmental nucleus and with lower levels in the hippocampus and olfactory regions. Significant expression is also observed in the spleen, thymus, lung and ovary. Relaxin 3 inhibits Forskolin-stimulated cAMP accumulation in a dose-dependent manner in cells that express Relaxin receptor 3. Acute and repeated administration of Relaxin 3 causes a decrease in levels of the plasma thyroid stimulating hormone, suggesting that Relaxin 3 may play a role in long-term control of food intake.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: insulin-like 7; Insulin-like peptide 7; Insulin-like peptide INSL7; PRO20213; Prorelaxin H3; Prorelaxin M3; Relaxin-3; UNQ6188
Gene Aliases: H3; INSL7; M3; RLN3; RXN3; UNQ6188/PRO20213; ZINS4
UniProt ID: (Human) Q8WXF3, (Mouse) Q8CHK2
Entrez Gene ID: (Human) 117579, (Mouse) 212108
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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