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RNase 4 and RNase 5/ang 1 are unique among the RNase A ribonuclease genes in that they maintain a complex gene locus that is conserved across species with transcription initiated from tissue-specific dual promoters followed by differential exon splicing. Rnase4 (ribonuclease, RNase A family 4) gene can produce 2 transcripts both encoding 148 amino acid proteins. Rnase 4 is a member of the pancreatic-type of secretory ribonucleases, a subset of the ribonuclease A superfamily. RNase 4 prefers poly(C) as a substrate and hydrolyzes 2',3'-cyclic nucleotides, with a pH optimum near 8.0. mRNA encoding RNase 4 is detectable in human pancreas, lung, skeletal muscle, heart, kidney and placenta; liver represents the most abundant source.
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Protein Aliases: Ribonuclease 4; ribonuclease A B1; ribonuclease, RNase A family, 4; RL3; RNase 4
Gene Aliases: C730049F20Rik; RAB1; RNASE4; RNS4
UniProt ID: (Human) P34096, (Rat) O55004
Entrez Gene ID: (Human) 6038, (Mouse) 58809, (Rat) 56759
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