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Proteintech
RNASEH2A Polyclonal Antibody
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Product Details
16132-1-AP
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse
Published species
Mouse
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
RNASEH2A Fusion Protein Ag9118 (1-299 aa encoded by BC011748)
Conjugate
Form
Liquid
Concentration
0.31 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Wet ice (domestic); Dry ice (international)
Product Specific Information
Immunogen sequence: MDLSELERD NTGRCRLSSP VPAVCRKEPC VLGVDEAGRG PVLGPMVYAI CYCPLPRLAD LEALKVADSK TLLESERERL FAKMEDTDFV GWALDVLSPN LISTSMLGRV KYNLNSLSHD TATGLIQYAL DQGVNVTQVF VDTVGMPETY QARLQQSFPG IEVTVKAKAD ALYPVVSAAS ICAKVARDQA VKKWQFVEKL QDLDTDYGSG YPNDPKTKAW LKEHVEPVFG FPQFVRFSWR TAQTILEKEA EDVIWEDSAS ENQEGLRKIT SYFLNEGSQA RPRSSHRYFL ERGLESATSL (1-299 aa encoded by BC011748)
Target Information
Ribonucleases (RNAses) H are enzymes that hydrolyze the RNA strands of RNA/DNA hybrids. The major role of these enzymes is to remove the RNA strand from the RNA/DNA hybrids that form during DNA replication and repair. RNAse H2 is made up of three subunits; all three are required for RNAse activity. Recent evidence has demonstrated that mutations in RNAse H2A or any of the other subunits result in Aicardi-Goutieres syndrome (AGS), a neurological disorder with similar symptoms to viral brain infections including high levels of IFN-alpha in the cerebral spinal fluid. Similar conditions are observed with mutations in TREX1, a single-stranded DNA exonuclease, suggesting that RNAse H2 and TREX1 may have similar roles, and that mutations in any of these genes lead to an accumulation of intracellular nucleic acids, triggering an inflammatory response through activation of the innate immune system.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: AGS4; Aicardi-Goutieres syndrome 4 protein; JUNB; Ribonuclease H2 subunit A; ribonuclease H2, large subunit; ribonuclease HI; Ribonuclease HI large subunit; Ribonuclease HI subunit A; RNase H(35); RNase H2 subunit A; RNase HI large subunit; unnamed protein product
Gene Aliases: 2400006P09Rik; AGS4; JUNB; RNASEH2A; RNASEHI; RNHIA; RNHL
UniProt ID: (Human) O75792, (Mouse) Q9CWY8
Entrez Gene ID: (Human) 10535, (Mouse) 69724
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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