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Proteintech
RNASEL Polyclonal Antibody, CoraLite® Plus 488
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Product Details
CL488-22577
Product Specifications
Species Reactivity
Human,
Mouse
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
RNASEL fusion protein Ag17409
Conjugate
Excitation/Emission Max
493/522 nm
Form
Liquid
Concentration
1000 µg/mL
Purification
Affinity chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol, 0.5% BSA
Contains
0.05% ProClin 300
Storage conditions
-20°C, store in dark
Shipping conditions
Wet ice
Product Specific Information
Sequence of this protein is as follows: KTFCEGSPRA QREVSCLQSS RENSHLVTFY GSESHRGHLF VCVTLCEQTL EACLDVHRGE DVENEEDEFA QNVLSSIFKA VQELHLSCGY THQDLQPQNI LIDSKKAAHL ADFDKSIKWA GDPQEVKRDL EDLGRLVLYV VKKGSISFEE LKAQSNEEVV QLSPDEETKD LIHRLFHPGE HVRDCLSDLL GHPFFWTWES RYRTLRNVGN ESDIKTRKSE SEILRLLQPG PSEHSKSFDK WTTKINECVM KKMNKFYEKR GNFYQNTVGD LLKFIRNLGE HIDEEKHKKM KLKIGDPSLY FQKTFPDLVI YVYTKLQNTE YRKHFPQTHS PNKPQCDGAG GASGLASPGC
Target Information
A virally induced endoribonuclease, RNase L is the terminal factor of the anti-viral action of interferon. Activation of RNase L results in inhibition of viral proliferation. Activation of RNase L has also been determined to degrade RNA, thus, initiating a cellular stress response, inducing apoptosis. Since mutations in RNase L relate to an increased incidence of prostate cancer, the activation of RNase L functions in counteracting prostate cancer, via apoptosis.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: 2',5'-oligoisoadenylate synthetase-dependent; 2-5A-dependent ribonuclease; 2-5A-dependent RNAase; 2-5A-dependent RNase; interferon-induced 2-5A-dependent RNase; Ribonuclease 4; Ribonuclease L; ribonuclease L (2',5'-oligoisoadenylate synthetase-dependent); RNase L
Gene Aliases: E230029I04Rik; PRCA1; RNASEL; RNS4
UniProt ID: (Human) Q05823, (Mouse) Q05921
Entrez Gene ID: (Human) 6041, (Mouse) 24014
RNA binding
endoribonuclease activity
protein kinase activity
protein binding
ATP binding
rRNA binding
ribonucleoprotein complex binding
metal ion binding
nucleotide binding
nuclease activity
endonuclease activity
ribonuclease activity
bidentate ribonuclease III activity
transferase activity, transferring phosphorus-containing groups
hydrolase activity
rRNA processing
mRNA processing
protein phosphorylation
regulation of mRNA stability
negative regulation of viral genome replication
fat cell differentiation
positive regulation of transcription from RNA polymerase II promoter
defense response to virus
RNA phosphodiester bond hydrolysis
positive regulation of glucose import in response to insulin stimulus
transmembrane transport
type I interferon signaling pathway
RNA phosphodiester bond hydrolysis, endonucleolytic
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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