A suggested positive control is SW480 cell lysate.
PA5-34346 can be used with blocking peptide PEP-1389.
RNASET2 is a novel member of the Rh/T2/S-glycoprotein class of extracellular ribonucleases. It is a single copy gene that maps to 6q27, a region associated with human malignancies and chromosomal rearrangement, and has been suggested to function as a tumor suppressor protein. Its expression is suppressed in Human T-cell Leukemia Virus type 1 (HTLV-1) infected cells following the binding of the HTLV-1 Tax protein to the RNASET2 promoter. As Adult T-cell leukemia (ATL) is one of the primary diseases caused by HTLV-1 infection, a reduction in the level of RNASET2 by Tax may play a role in ATL development.
Protein Aliases: Ribonuclease 6; Ribonuclease 6-A; Ribonuclease 6-B; Ribonuclease T2; Ribonuclease T2-A; Ribonuclease T2-B; RNase T2; rnt2; RP11-514O12.3
Gene Aliases: 0610007O07Rik; 4833423A10Rik; 4930532K22Rik; bA514O12.3; C79750; RNASE6PL; RNASET2; Rnaset2a; Rnaset2b