Immunogen sequence: GTPSDEDNDS SFSDCLSSPS SSLHFGDSDT VTSDEDKEVS VRHSQTILNA KSRSHSARSH KWPRTETESV SGLLMKRPCL HGSSLRRLPC
Highest antigen sequence identity to the following orthologs: Mouse - 81%, Rat - 86%.
The protein encoded by this gene is a nuclear RING-domain containing E3 ubiquitin ligase. This protein interacts with the transforming growth factor (TGF) -beta/NODAL signaling pathway by promoting the ubiquitination and proteosomal degradation of negative regulators, like SMAD proteins, and thereby enhances TGF-beta target-gene transcription. As a modulator of the nodal signaling cascade, this gene plays a critical role in the induction of mesoderm during embryonic development. Alternative splicing of this gene results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Jul 2012].
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Protein Aliases: Arkadia; E3 ubiquitin-protein ligase Arkadia; hRNF111; RING finger protein 111; RING-type E3 ubiquitin transferase Arkadia
Gene Aliases: ARK; Arkadia; RNF111