Search Thermo Fisher Scientific
Disclaimer
Clicking the images or links will redirect you to a website hosted by BenchSci that provides third-party scientific content. Neither the content nor the BenchSci technology and processes for selection have been evaluated by us; we are providing them as-is and without warranty of any kind, including for use or application of the Thermo Fisher Scientific products presented.
Product Details
PA5-51534
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant protein corresponding to Human RNF139. Recombinant protein control fragment (Product #RP-96771).
Conjugate
Form
Liquid
Concentration
0.1 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.2, with 40% glycerol
Contains
0.02% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Wet ice
RRID
AB_2646625
Product Specific Information
Immunogen sequence: PEIKGSRLQE INDVCAICYH EFTTSARITP CNHYFHALCL RKWLYIQDTC PMCHQKVYIE DDIKDNSNVS NNNGFIPPNE TPEEAVREAA AESDRELNED DSTDCDDDVQ RERNGVIQHT GAAAEEF
Highest antigen sequence identity to the following orthologs: Mouse - 88%, Rat - 88%.
Target Information
The protein encoded by this gene is a multi-membrane spanning protein containing a RING-H2 finger. This protein is located in the endoplasmic reticulum, and has been shown to possess ubiquitin ligase activity. This gene was found to be interrupted by a ttranslocation in a family with hereditary renal and non-medulary thyroid cancer. Studies of the Drosophila counterpart suggested that this protein may interact with tumor suppressor protein VHL, as well as with COPS5/JAB1, a protein responsible for the degradation of tumor suppressor CDKN1B/P27KIP.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
References (0)
Have you cited this product in a publication?
Let us know so we can reference it here.
Bioinformatics
Protein Aliases: E3 ubiquitin-protein ligase RNF139; MGC31961; multiple membrane spanning receptor TRC8; patched related protein translocated in renal cancer; RING finger protein 139; RING-type E3 ubiquitin transferase RNF139; RNF139; Translocation in renal carcinoma on chromosome 8 protein
Gene Aliases: HRCA1; RCA1; RNF139; TRC8
UniProt ID: (Human) Q8WU17
Entrez Gene ID: (Human) 11236
protein polyubiquitination
negative regulation of cell proliferation
protein ubiquitination
negative regulation of translation
regulation of protein ubiquitination
protein destabilization
ERAD pathway
proteasome-mediated ubiquitin-dependent protein catabolic process
regulation of ER to Golgi vesicle-mediated transport
regulation of protein processing
positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
Learn more
We're here to help
Get expert recommendations for common problems or connect directly with an on staff expert for technical assistance related to applications, equipment and general product use.
Contact tech support