|Western Blot (WB)||1:500-1:3000|
|Tested Species reactivity||Human|
|Host / Isotype||Rabbit / IgG|
|Immunogen||Recombinant fragment corresponding to a region within amino acids 1 and 260 of Human RNF14|
|Purification||Antigen affinity chromatography|
|Storage buffer||PBS, pH 7, with 1% BSA, 20% glycerol|
|Storage conditions||-20° C, Avoid Freeze/Thaw Cycles|
PA5-29456 targets RNF14 in WB applications and shows reactivity with Human samples.
The PA5-29456 immunogen is recombinant fragment corresponding to a region within amino acids 1 and 260 of Human RNF14.
The protein encoded by this gene contains a RING zinc finger, a motif known to be involved in protein-protein interactions. This protein interacts with androgen receptor (AR) and may function as a coactivator that induces AR target gene expression in prostate. A dominant negative mutant of this gene has been demonstrated to inhibit the AR-mediated growth of prostate cancer. This protein also interacts with class III ubiquitin-conjugating enzymes (E2s) and may act as a ubiquitin-ligase (E3) in the ubiquitination of certain nuclear proteins. Five alternatively spliced transcript variants encoding two distinct isoforms have been reported.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: androgen receptor associated protein 54; Androgen receptor-associated protein 54; ARA54; E3 ubiquitin-protein ligase RNF14; HFB30; RING finger protein 14; TRIAD2; Triad2 protein
Gene Aliases: ARA54; HFB30; HRIHFB2038; RNF14; TRIAD2
UniProt ID: (Human) Q9UBS8
Entrez Gene ID: (Human) 9604
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