Immunogen sequence: PCRGCNKKVT LAKMRVHISS CLKVQEQMAN CPKFVPVVPT SQPIPSNIPN RSTFACPYCG ARNLDQQELV KHCVESHRSD PNRVVCPICS AMP
RNF166 (RING finger protein 166) is a 237 amino acid protein that contains one RING-type zinc finger and a UIM (ubiquitin-interacting motif) repeat. Existing as two alternatively spliced isoforms, RNF166 is encoded by a gene that maps to human chromosome 16q24.3. Chromosome 16 encodes over 900 genes and comprises nearly 3% of the human genome. The GAN gene is located on chromosome 16 and, with mutation, may lead to giant axonal neuropathy, a nervous system disorder characterized by increasing malfunction with growth. The rare disorder Rubinstein-Taybi syndrome is also associated with chromosome 16, as is Crohn's disease, which is a gastrointestinal inflammatory condition.
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Protein Aliases: E3 ubiquitin-protein ligase RNF166; RING finger protein 166; RING-type E3 ubiquitin transferase RNF166
Gene Aliases: RNF166
UniProt ID: (Human) Q96A37
Entrez Gene ID: (Human) 115992