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RNF186 Polyclonal Antibody
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Product Details
BS-9262R
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
KLH conjugated synthetic peptide derived from human RNF186.
Conjugate
Form
Liquid
Concentration
1 mg/mL
Amount
100 µg
Purification
Protein A
Storage buffer
0.01M TBS, pH 7.4, with 1% BSA, 50% glycerol
Contains
0.02% ProClin 300
Storage conditions
-20°C
Shipping conditions
Ambient (domestic); Wet ice (international)
Target Information
The RNF186 gene encodes the RING finger protein 186, a member of the RING-type E3 ubiquitin ligase family. RNF186 is involved in the ubiquitin-proteasome pathway, playing a crucial role in tagging target proteins for degradation, thus influencing protein turnover and cellular homeostasis. This process is essential for regulating various cellular functions, including signal transduction, apoptosis, and response to stress. RNF186 has been implicated in the unfolded protein response (UPR) within the endoplasmic reticulum, where it helps in managing protein folding and maintaining cellular homeostasis, particularly under conditions of endoplasmic reticulum stress. Alterations in RNF186 expression or function have been associated with disorders such as inflammatory bowel disease and ulcerative colitis, suggesting its role in gastrointestinal health and disease. Research into RNF186 focuses on its regulatory mechanisms within the ubiquitin-proteasome system and its potential as a therapeutic target for conditions associated with protein misfolding and cellular stress responses.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: E3 ubiquitin-protein ligase RNF186; FLJ20225; RING finger protein 186; unnamed protein product
Gene Aliases: 9130020G10Rik; RNF186
UniProt ID: (Human) Q9NXI6, (Mouse) Q9D241
Entrez Gene ID: (Human) 54546, (Mouse) 66825, (Rat) 690433
protein ubiquitination
protein K29-linked ubiquitination
proteasome-mediated ubiquitin-dependent protein catabolic process
protein autoubiquitination
intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress
protein K63-linked ubiquitination
protein localization to mitochondrion
apoptotic process in response to mitochondrial fragmentation
regulation of autophagosome assembly
biological_process
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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