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Product Details
PA5-103251
| Applications | Tested Dilution | Publications |
|---|---|---|
Western Blot (WB) |
1:1,000-1:3,000 | - |
Immunocytochemistry (ICC/IF) |
1:100-1:500 | - |
| Product Specifications | |
|---|---|
Species Reactivity |
Human, Mouse |
Host/Isotype |
Rabbit / IgG |
Class |
Polyclonal |
Type |
Antibody |
Immunogen |
A synthesized peptide derived from human RNF19A, corresponding to a region within N-terminal amino acids. |
Conjugate |
Unconjugated |
Form |
Liquid |
Concentration |
1 mg/mL |
Purification |
Affinity chromatography |
Storage buffer |
PBS, pH 7.4, with 50% glycerol |
Contains |
0.02% sodium azide |
Storage conditions |
-20°C |
RRID |
AB_2852614 |
Target Information
This gene encodes a member of the ring between ring fingers (RBR) protein family, and the encoded protein contains two RING-finger motifs and an in between RING fingers motif. This protein is an E3 ubiquitin ligase that is localized to Lewy bodies, and ubiquitylates synphilin-1, which is an interacting protein of alpha synuclein in neurons. The encoded protein may be involved in amyotrophic lateral sclerosis and Parkinson's disease. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2013].
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: Dorfin; Double ring-finger protein; E3 ubiquitin-protein ligase RNF19A; Gametogenesis-expressed protein GEG-154; p38; protein p38 interacting with transcription factor Sp1; ring finger protein (C3HC4 type) 19; ring finger protein 19; RING finger protein 19A; ring finger protein 19A, E3 ubiquitin protein ligase; ring-IBR-ring domain containing protein Dorfin; UBCM4-interacting protein 117; ubiquitin conjugating enzyme 7 interacting protein 2; UIP117; XY body protein; XYbp
Gene Aliases: AA032313; Dorfin; Geg-154; RNF19; RNF19A; Ubce7ip2; UIP117; XYbp
UniProt ID: (Human) Q9NV58, (Mouse) P50636
Entrez Gene ID: (Human) 25897, (Mouse) 30945
Molecular Function:
ubiquitin-protein ligase
ubiquitin-protein transferase activity
transcription factor binding
zinc ion binding
ligase activity
ubiquitin conjugating enzyme binding
ubiquitin protein ligase activity
protein binding
UDP-N-acetylmuramoylalanyl-D-glutamyl-2,6-diaminopimelate-D-alanyl-D-alanine ligase activity
ribosomal S6-glutamic acid ligase activity
coenzyme F420-0 gamma-glutamyl ligase activity
coenzyme F420-2 alpha-glutamyl ligase activity
metal ion binding
protein-glycine ligase activity
protein-glycine ligase activity, initiating
protein-glycine ligase activity, elongating
tubulin-glycine ligase activity
protein-glutamic acid ligase activity
tubulin-glutamic acid ligase activity
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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