Immunogen sequence: ELALSLLQET PRNYELGDVV EAVRHSQDRA FLRRLLAQEC AVCGWALPHN RMQALTSCEC TICPDCFRQH FTIALKEKHI TDMVCPACGR PDLTDDTQLL SYFSTLDIQL RESLEPDAYA LFHKKLTEGV
Highest antigen sequence identity to the following orthologs: Mouse - 94%, Rat - 95%.
Lyn proto oncogene (Lcl/Yes related novel protein tyrosine kinase) is encoded by the Lyn gene located on chromosome 8 in humans and belongs to the Src family kinase. It is a non-receptor tyrosine kinase that acts as a mediator in transducing cellular signaling. The most well studied expression of Lyn is in hematopoietic cell types, both lymphoid and myeloid cells with exclusion in T lymphocytes. It has also been observed that Lyn plays diverse roles such as in regulation of B cell receptor signaling, mast cell signaling and Epithelial - Mesenchymal Transition (EMT).
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Protein Aliases: E3 ubiquitin-protein ligase RNF31; FLJ10111; FLJ23501; HOIL-1-interacting protein; HOIP; MGC19975; RING finger protein 31; RING-type E3 ubiquitin transferase RNF31; RNF31; ZIBRA; zinc in-between-ring-finger ubiquitin-associated domain; Zinc in-between-RING-finger ubiquitin-associated domain protein
Gene Aliases: HOIP; RNF31; ZIBRA
UniProt ID: (Human) Q96EP0
Entrez Gene ID: (Human) 55072