The protein encoded by this gene contains a RINF finger, a motif known to be involved in protein-protein and protein-DNA interactions. This protein interacts with DNAJA3/hTid-1, which is a DnaJ protein reported to function as a modulator of apoptosis. Overexpression of this gene in Hela cells was shown to confer the resistance to TNF-alpha induced apoptosis, suggesting an anti-apoptotic function of this protein. This protein can be cleaved by caspase-3 during the induction of apoptosis. Alternatively spliced transcript variants encoding distinct isoforms have been reported.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: CARP 1; CARP-1; Caspase regulator CARP1; Caspases-8 and -10-associated RING finger protein 1; E3 ubiquitin-protein ligase RNF34; FYVE RING finger protein Momo; FYVE-RING finger protein MOMO; hRFI; Human RING finger homologous to inhibitor of apoptosis protein; phafin 1; Phafin-1; RFI; RIF; RIFF; RING finger protein 34; ring finger protein 34, E3 ubiquitin protein ligase; RING finger protein MOMO; RING finger protein RIFF; RING-type E3 ubiquitin transferase RNF34; RNF34
Gene Aliases: AW061037; AW536122; BC004042; C88279; CARP-1; CARP1; hRFI; Momo; RFI; RIF; RIFF; RNF34