The protein encoded by this gene contains a RINF finger, a motif known to be involved in protein-protein and protein-DNA interactions. This protein interacts with DNAJA3/hTid-1, which is a DnaJ protein reported to function as a modulator of apoptosis. Overexpression of this gene in Hela cells was shown to confer the resistance to TNF-alpha induced apoptosis, suggesting an anti-apoptotic function of this protein. This protein can be cleaved by caspase-3 during the induction of apoptosis. Alternatively spliced transcript variants encoding distinct isoforms have been reported.
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Protein Aliases: CARP-1; Caspase regulator CARP1; Caspases-8 and -10-associated RING finger protein 1; E3 ubiquitin-protein ligase RNF34; FLJ21786; FYVE-RING finger protein MOMO; hRFI; Human RING finger homologous to inhibitor of apoptosis protein; phafin 1; Phafin-1; RING finger protein 34; ring finger protein 34, E3 ubiquitin protein ligase; RING finger protein MOMO; RING finger protein RIFF; RING-type E3 ubiquitin transferase RNF34
Gene Aliases: AW061037; AW536122; BC004042; C88279; CARP-1; CARP1; hRFI; Momo; RFI; RIF; RIFF; RNF34
Molecular Function: ubiquitin-protein ligase