Immunogen sequence: SGTVYHNSQR ESRPVQQTTR RSVRRRGRTR VFLEQDRERE RRGTAYTPFS NSRLVSRITV EEGEESSRSS TAVRR
Highest antigen sequence identity to the following orthologs: Mouse - 76%, Rat - 72%.
The protein encoded by this gene contains a RING-H2 finger motif. Deletions and mutations in this gene were detected in esophageal squamous cell carcinoma (ESCC), suggesting that this protein may be a potential tumor suppressor. Studies of the mouse counterpart suggested a role of this protein in the transcription regulation that controls germinal differentiation. Multiple alternatively spliced transcript variants encoding the same protein are observed.
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Protein Aliases: E3 ubiquitin-protein ligase RNF6; ring finger protein (C3H2C3 type) 6; RING-H2 protein RNF-6; RING-type E3 ubiquitin transferase RNF6
Gene Aliases: RNF6; SPG2
UniProt ID: (Human) Q9Y252
Entrez Gene ID: (Human) 6049