The protein encoded by this gene is a highly conserved ring finger protein. It is an essential subunit of SKP1-cullin/CDC53-F box protein ubiquitin ligases, which are a part of the protein degradation machinery important for cell cycle progression and signal transduction. This protein interacts with, and is a substrate of, casein kinase II (CSNK2A1/CKII). The phosphorylation of this protein by CSNK2A1 has been shown to promote the degradation of IkappaBalpha (CHUK/IKK-alpha/IKBKA) and p27Kip1(CDKN1B). Alternatively spliced transcript variants encoding distinct isoforms have been reported.
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Protein Aliases: CKBBP1; CKII beta binding protein 1; CKII beta-binding protein 1; Rbx2; Regulator of cullins 2; RING box protein 2; RING finger protein 7; RING-box protein 2; RNF7; ROC2; Sensitive to apoptosis gene protein; sensitive to apoptosis, zinc RING finger protein SAG, regulator of cullins 2; zinc RING finger protein SAG
Gene Aliases: CKBBP1; RBX2; RNF7; ROC2; SAG