The antibody detects endogenous levels of total RNF7 protein.
The protein encoded by this gene is a highly conserved ring finger protein. It is an essential subunit of SKP1-cullin/CDC53-F box protein ubiquitin ligases, which are a part of the protein degradation machinery important for cell cycle progression and signal transduction. This protein interacts with, and is a substrate of, casein kinase II and p27Kip1. Alternatively spliced transcript variants encoding distinct isoforms have been reported.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: CKBBP1; CKII beta-binding protein 1; RBX2; Regulator of cullins 2; RING finger protein 7; RING-box protein 2; ROC2; Sensitive to apoptosis gene protein; sensitive to apoptosis, zinc RING finger protein SAG, regulator of cullins 2; zinc RING finger protein SAG
Gene Aliases: CKBBP1; RBX2; RNF7; ROC2; SAG