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RNF74 Polyclonal Antibody
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Product Details
BS-6941R
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
KLH conjugated synthetic peptide derived from human RAG1/RNF74, amino acids 351-450.
Conjugate
Form
Liquid
Concentration
1 mg/mL
Purification
Protein A
Storage buffer
0.01M TBS, pH 7.4, with 50% glycerol, 1% BSA
Contains
0.02% ProClin 300
Storage conditions
-20°C
Shipping conditions
Ambient (domestic); Wet ice (international)
Target Information
The protein encoded by this gene is involved in activation of immunoglobulin V-D-J recombination. The encoded protein is involved in recognition of the DNA substrate, but stable binding and cleavage activity also requires RAG2. Defects in this gene can be the cause of several diseases.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: MGC43321; RAG-1; RAG-1 Antibody; recombinase activating gene 1; recombination activating gene 1; recombination activating gene 1 Antibody; recombination activating protein; recombination activating protein 1; recombination activation protein 1; recombination-activating gene 1; RING finger protein 74; RNF74 Antibody; V(D)J recombination-activating protein 1
Gene Aliases: RAG-1; RAG1; RNF74
UniProt ID: (Human) P15918, (Mouse) P15919
Entrez Gene ID: (Human) 5896, (Rat) 84600, (Mouse) 19373
DNA binding
catalytic activity
nuclease activity
endonuclease activity
ubiquitin-protein transferase activity
protein binding
zinc ion binding
transferase activity
hydrolase activity
histone binding
identical protein binding
protein homodimerization activity
sequence-specific DNA binding
metal ion binding
ubiquitin protein ligase activity
double-stranded DNA endodeoxyribonuclease activity
molecular_function
nucleic acid binding
UDP-N-acetylmuramoylalanyl-D-glutamyl-2,6-diaminopimelate-D-alanyl-D-alanine ligase activity
hydrolase activity, acting on ester bonds
ligase activity
acid-amino acid ligase activity
ribosomal S6-glutamic acid ligase activity
phosphoric ester hydrolase activity
T/G mismatch-specific endonuclease activity
coenzyme F420-0 gamma-glutamyl ligase activity
coenzyme F420-2 alpha-glutamyl ligase activity
retroviral 3' processing activity
protein-glycine ligase activity
protein-glycine ligase activity, initiating
protein-glycine ligase activity, elongating
tubulin-glycine ligase activity
protein-glutamic acid ligase activity
tubulin-glutamic acid ligase activity
DNA metabolism protein
endodeoxyribonuclease
nucleic acid metabolism protein
adaptive immune response
pre-B cell allelic exclusion
DNA recombination
chromatin organization
immune response
visual learning
B cell differentiation
T cell differentiation in thymus
V(D)J recombination
T cell homeostasis
regulation of T cell differentiation
positive regulation of T cell differentiation
thymus development
protein autoubiquitination
negative regulation of T cell apoptotic process
negative regulation of thymocyte apoptotic process
regulation of behavioral fear response
metabolic process
histone monoubiquitination
obsolete death
chromatin modification
negative regulation of cysteine-type endopeptidase activity involved in apoptotic process
nucleic acid phosphodiester bond hydrolysis
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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