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Immunogen sequence: MDLSGVKKK SLLGVKENNK KSSTRAPSPT KRKDRSDEKS KDRSKDKGAT KESSEKDRGR DKTRKRRSAS SGSSSTRSRS SSTSSSGSST STGSSSGSSS SSASSRSGSS STSRSSSSSS SSGSPSPSRR RHDNRRRSRS KSKPPKRDEK ERKRRSPSPK PTKVHIGRLT RNVTKDHIME IFSTYGKIKM IDMPVERMHP HLSKGYAYVE FENPDEAEKA LKHMDGGQID GQEITATAVL APWPRPPPRR FSPPRRMLPP PPMWRRSPPR MRRRSRSPRR RSPVRRRSRS PGRRRHRSRS SSNSSR (1-305 aa encoded by B C001838)
This gene encodes a protein that is part of a post-splicing multiprotein complex involved in both mRNA nuclear export and mRNA surveillance. mRNA surveillance detects exported mRNAs with truncated open reading frames and initiates nonsense-mediated mRNA decay (NMD). When translation ends upstream from the last exon-exon junction, this triggers NMD to degrade mRNAs containing premature stop codons. This protein binds to the mRNA and remains bound after nuclear export, acting as a nucleocytoplasmic shuttling protein. This protein contains many serine residues. Two splice variants have been found for this gene; both variants encode the same protein.
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