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Rockland
ROC2 Polyclonal Antibody
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Product Details
100-401-A14
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
This antibody was prepared from whole rabbit serum produced by repeated immunizations with a synthetic peptide corresponding to amino acids 102-113 of Human ROC2 (C-terminal) coupled to KLH.
Conjugate
Form
Liquid
Concentration
85 mg/mL
Amount
8.5 mg
Storage buffer
whole serum
Contains
0.01% sodium azide
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Wet ice (international)
Product Specific Information
Store vial at -20° C prior to opening. Aliquot contents and freeze at -20° C or below for extended storage. Avoid cycles of freezing and thawing. Centrifuge product if not completely clear after standing at room temperature. This product is stable for several weeks at 4° C as an undiluted liquid. Dilute only prior to immediate use.
This product reacts with human, mouse, C.elgans and zebra fish ROC2. Cross reactivity may also occur with ROC2 from other sources. Sufficient sequence differences exist to suggest that this antibody would not react with other RING box proteins such as ROC1 and APC11.
Target Information
The protein encoded by this gene is a highly conserved ring finger protein. It is an essential subunit of SKP1-cullin/CDC53-F box protein ubiquitin ligases, which are a part of the protein degradation machinery important for cell cycle progression and signal transduction. This protein interacts with, and is a substrate of, casein kinase II (CSNK2A1/CKII). The phosphorylation of this protein by CSNK2A1 has been shown to promote the degradation of IkappaBalpha (CHUK/IKK-alpha/IKBKA) and p27Kip1(CDKN1B). Alternatively spliced transcript variants encoding distinct isoforms have been reported.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: CKBBP1; CKII beta-binding protein 1; OTTHUMP00000180645; Rbx2; Regulator of cullins 2; RING finger protein 7; RING-box protein 2; SAG; SAG-v; Sensitive to apoptosis gene protein; sensitive to apoptosis zinc RING finger protein SAG; sensitive to apoptosis, zinc RING finger protein SAG, regulator of cullins 2; unnamed protein product; zinc RING finger protein SAG
Gene Aliases: CKBBP1; RBX2; RNF7; ROC2; SAG
UniProt ID: (Human) Q9UBF6
Entrez Gene ID: (Human) 9616
epithelial to mesenchymal transition
ubiquitin-dependent protein catabolic process
proteasomal protein catabolic process
protein ubiquitination
layer formation in cerebral cortex
positive regulation of cell migration
endoplasmic reticulum unfolded protein response
SCF-dependent proteasomal ubiquitin-dependent protein catabolic process
intracellular signal transduction
reelin-mediated signaling pathway
erythropoietin-mediated signaling pathway
proteasome-mediated ubiquitin-dependent protein catabolic process
post-translational protein modification
innate immune response
protein neddylation
phosphocreatine biosynthetic process
defense response to virus
response to redox state
positive regulation of focal adhesion assembly
negative regulation of focal adhesion assembly
growth hormone receptor signaling pathway
JAK-STAT cascade involved in growth hormone signaling pathway
negative regulation of growth hormone receptor signaling pathway
protein K11-linked ubiquitination
negative regulation of focal adhesion disassembly
cGAS/STING signaling pathway
regulation of neuron migration
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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