This Antibody was verified by KnockDown to ensure that the antibody binds to the antigen stated. View Details
PA5-32219 targets ROCK1 in WB applications and shows reactivity with Human samples.
The PA5-32219 immunogen is synthetic peptide corresponding to a region within amino acids 1272 and 1366 of Human ROCK1.
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This gene encodes a protein serine/threonine kinase that is activated when bound to the GTP-bound form of Rho. The small GTPase Rho regulates formation of focal adhesions and stress fibers of fibroblasts, as well as adhesion and aggregation of platelets and lymphocytes by shuttling between the inactive GDP-bound form and the active GTP-bound form. Rho is also essential in cytokinesis and plays a role in transcriptional activation by serum response factor. This protein, a downstream effector of Rho, phosphorylates and activates LIM kinase, which in turn, phosphorylates cofilin, inhibiting its actin-depolymerizing activity.
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Protein Aliases: coiled-coil-containing protein kinase 1; coiled-coil-containing protein kinase I; p160 ROCK-1; p160-ROCK; P160ROCK; Renal carcinoma antigen NY-REN-35; Rho kinase; rho-associated; Rho-associated protein kinase 1; Rho-associated, coiled-coil containing protein kinase 1; Rho-associated, coiled-coil-containing protein kinase 1; Rho-associated, coiled-coil-containing protein kinase I; ROCK-I
Gene Aliases: P160ROCK; ROCK-I; ROCK1
UniProt ID: (Human) Q13464
Entrez Gene ID: (Human) 6093