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Invitrogen

ROCK1/ROCK2 Recombinant Rabbit Monoclonal Antibody (HL1632)

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Product Details

MA5-50324

Applications
Tested Dilution
Publications

Western Blot (WB)

1:500-1:10,000
-

Immunohistochemistry (Paraffin) (IHC (P))

Assay-dependent
-

Immunocytochemistry (ICC/IF)

Assay-dependent
-
Product Specifications

Species Reactivity

Human, Mouse, Rat

Host/Isotype

Rabbit / IgG

Expression System

HEK293 cells

Class

Recombinant Monoclonal

Type

Antibody

Clone

HL1632

Immunogen

Recombinant fragment of human ROCK1 .

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

1 mg/mL

Amount

100 µg

Purification

Protein A

Storage buffer

PBS

Contains

no preservative

Storage conditions

Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

Shipping conditions

Ambient (domestic); Wet ice (international)

RRID

AB_3093954

Target Information

ROCK1 and ROCK2 are genes that encode for Rho-associated coiled-coil containing protein kinases, also known as ROCKs. These kinases are involved in a variety of cellular processes such as cell migration, adhesion, proliferation, and apoptosis. They are activated by the small GTPase RhoA and phosphorylate downstream targets such as myosin light chain, LIM kinase, and myosin phosphatase. Dysregulation of ROCK1 and ROCK2 has been linked to various diseases including cancer, cardiovascular disease, and neurological disorders.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: liver regeneration-related protein LRRG199; p150 RhoA-binding kinase ROK beta; p150 ROK-alpha; p160 ROCK-1; p160ROCK; p164 ROCK-2; Renal carcinoma antigen NY-REN-35; Rho kinase 2; Rho-associated coiled-coil forming kinage 2; Rho-associated coiled-coil forming kinase 1; Rho-associated coiled-coil forming kinase 2; Rho-associated kinase beta; Rho-associated protein kinase 1; Rho-associated protein kinase 2; Rho-associated, coiled-coil-containing protein kinase 1; Rho-associated, coiled-coil-containing protein kinase 2; Rho-associated, coiled-coil-containing protein kinase I; Rho-associated, coiled-coil-containing protein kinase II; RhoA - binding serine/threosine kinase alpha (ROK - alpha); RhoA-binding kinase 2; ROCK-1/ROCK-2; ROCK-I; ROCK-I/ROCK-II; ROCK-II; ROKalpha; unnamed protein product

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Gene Aliases: 1110055K06Rik; B230113H15Rik; KIAA0619; mKIAA0619; P160ROCK; Rho-kinase; ROCK-I; ROCK-II; ROCK1; ROCK2; Rock2m; ROK; ROKalpha

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UniProt ID: (Human) Q13464, (Human) O75116, (Mouse) P70335, (Rat) Q62868, (Mouse) P70336

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Entrez Gene ID: (Human) 6093, (Human) 9475, (Mouse) 19877, (Rat) 81762, (Rat) 25537, (Mouse) 19878

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Function(s)
nucleotide binding protein kinase activity protein serine/threonine kinase activity protein binding ATP binding zinc ion binding kinase activity transferase activity small GTPase binding metal ion binding tau protein binding tau-protein kinase activity Rho-dependent protein serine/threonine kinase activity protein serine kinase activity protease binding RNA binding structural molecule activity endopeptidase activator activity transferase activity, transferring phosphorus-containing groups Rho GTPase binding GTP-Rho binding poly(A) RNA binding non-receptor serine/threonine protein kinase
Process(es)
mitotic cytokinesis epithelial to mesenchymal transition aortic valve morphogenesis apical constriction apoptotic process smooth muscle contraction leukocyte cell-cell adhesion signal transduction Rho protein signal transduction regulation of gene expression positive regulation of autophagy positive regulation of macromolecule metabolic process positive regulation of cardiac muscle hypertrophy positive regulation of gene expression negative regulation of angiogenesis peptidyl-serine phosphorylation membrane to membrane docking actin cytoskeleton organization regulation of cell adhesion regulation of cell migration cortical actin cytoskeleton organization actomyosin structure organization neuron projection development bleb assembly negative regulation of protein binding regulation of actin cytoskeleton organization regulation of actin filament-based process intracellular signal transduction positive regulation of MAPK cascade regulation of keratinocyte differentiation regulation of neuron differentiation positive regulation of phosphate metabolic process embryonic morphogenesis leukocyte migration leukocyte tethering or rolling negative regulation of membrane protein ectodomain proteolysis myoblast migration regulation of stress fiber assembly regulation of focal adhesion assembly positive regulation of focal adhesion assembly mRNA destabilization negative regulation of biomineral tissue development regulation of microtubule cytoskeleton organization response to transforming growth factor beta protein localization to plasma membrane regulation of synapse maturation glomerular visceral epithelial cell migration motor neuron apoptotic process regulation of blood vessel diameter regulation of angiotensin-activated signaling pathway neuron projection arborization positive regulation of beta-amyloid clearance regulation of synaptic vesicle endocytosis regulation of cell junction assembly regulation of beta-amyloid formation negative regulation of beta-amyloid formation negative regulation of amyloid precursor protein catabolic process regulation of establishment of endothelial barrier negative regulation of bicellular tight junction assembly positive regulation of connective tissue replacement response to angiotensin regulation of establishment of cell polarity regulation of cell motility negative regulation of motor neuron apoptotic process response to ischemia protein phosphorylation negative regulation of gene expression positive regulation of centrosome duplication positive regulation of cell migration regulation of neurological system process positive regulation of connective tissue growth factor production regulation of circadian rhythm stress fiber assembly modulation by host of viral process negative regulation of nitric oxide biosynthetic process rhythmic process centrosome duplication positive regulation of stress fiber assembly positive regulation of fibroblast growth factor production negative regulation of protein localization to lysosome regulation of cellular response to hypoxia positive regulation of beta-amyloid formation positive regulation of protein localization to early endosome positive regulation of amyloid precursor protein catabolic process cellular response to acetylcholine cytoskeleton organization phosphorylation negative regulation of neuron apoptotic process regulation of cytoskeleton organization neural tube closure extrinsic apoptotic signaling pathway via death domain receptors chromosome condensation dendrite morphogenesis
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