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Invitrogen
ROCK1/ROCK2 Recombinant Rabbit Monoclonal Antibody (HL1632)
FIGURE: 1 / 7
ROCK1/ROCK2 Antibody (MA5-50324) in IHC (P)
Immunohistochemical analysis of ROCK1/ROCK2 using ROCK1/ROCK2 Recombinant Monoclonal Antibody (Product # MA5-50324) in Paraffin embedded rat brain and colon tissue at a dilution of 1:200. For Antigen retrieval citrate buffer, pH 6.0, as used for 15 min.
Product Details
MA5-50324
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Expression System
HEK293 cells
Class
Recombinant Monoclonal
Type
Antibody
Clone
HL1632
Immunogen
Recombinant fragment of human ROCK1 .
Conjugate
Form
Liquid
Concentration
1 mg/mL
Purification
Protein A
Storage buffer
PBS
Contains
no preservative
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
AB_3093954
Target Information
ROCK1 and ROCK2 are genes that encode for Rho-associated coiled-coil containing protein kinases, also known as ROCKs. These kinases are involved in a variety of cellular processes such as cell migration, adhesion, proliferation, and apoptosis. They are activated by the small GTPase RhoA and phosphorylate downstream targets such as myosin light chain, LIM kinase, and myosin phosphatase. Dysregulation of ROCK1 and ROCK2 has been linked to various diseases including cancer, cardiovascular disease, and neurological disorders.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: p160 ROCK-1; p160ROCK; p164 ROCK-2; Renal carcinoma antigen NY-REN-35; Rho kinase 2; Rho-associated protein kinase 1; Rho-associated protein kinase 2; Rho-associated, coiled-coil containing protein kinase 1; Rho-associated, coiled-coil-containing protein kinase 1; Rho-associated, coiled-coil-containing protein kinase 2; Rho-associated, coiled-coil-containing protein kinase I; Rho-associated, coiled-coil-containing protein kinase II; ROCK-1/ROCK-2; ROCK-I; ROCK-I/ROCK-II; ROCK-II
Gene Aliases: KIAA0619; P160ROCK; ROCK-I; ROCK-II; ROCK1; ROCK2
UniProt ID: (Human) Q13464, (Human) O75116
Entrez Gene ID: (Human) 6093, (Human) 9475
apical constriction
protein phosphorylation
cellular component disassembly involved in execution phase of apoptosis
smooth muscle contraction
leukocyte cell-cell adhesion
signal transduction
I-kappaB kinase/NF-kappaB signaling
Rho protein signal transduction
negative regulation of angiogenesis
membrane to membrane docking
actin cytoskeleton organization
regulation of cell adhesion
cortical actin cytoskeleton organization
bleb assembly
negative regulation of protein binding
regulation of actin cytoskeleton organization
negative regulation of myosin-light-chain-phosphatase activity
negative regulation of neuron apoptotic process
regulation of keratinocyte differentiation
vascular endothelial growth factor receptor signaling pathway
ephrin receptor signaling pathway
leukocyte migration
leukocyte tethering or rolling
myoblast migration
regulation of stress fiber assembly
regulation of focal adhesion assembly
positive regulation of focal adhesion assembly
establishment of protein localization to plasma membrane
regulation of establishment of endothelial barrier
negative regulation of bicellular tight junction assembly
regulation of establishment of cell polarity
regulation of cell motility
cytokinesis
positive regulation of protein phosphorylation
positive regulation of endothelial cell migration
positive regulation of gene expression
positive regulation of centrosome duplication
regulation of circadian rhythm
rhythmic process
centrosome duplication
cellular response to testosterone stimulus
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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