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Invitrogen

ROCK2 Polyclonal Antibody

View all (38) ROCK2 antibodies

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ROCK2 Polyclonal Antibody

Product Details

PA5-96400

Applications
Tested Dilution
Publications

Western Blot (WB)

1:500-1:1,000
-

Immunohistochemistry (Paraffin) (IHC (P))

1:50-1:200
-

Immunocytochemistry (ICC/IF)

1:50-1:200
-

ELISA (ELISA)

1 µg/mL
-
Product Specifications

Species Reactivity

Human, Mouse, Rat

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

Recombinant fusion protein containing a sequence corresponding to amino acids 1109-1388 of human ROCK2 (NP_0048412)
View immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.92 mg/mL

Amount

92 µg

Purification

Affinity Chromatography

Storage buffer

PBS, pH 7.3, with 50% glycerol

Contains

0.02% sodium azide

Storage conditions

-20°C, Avoid Freeze/Thaw Cycles

Shipping conditions

Ambient (domestic); Wet ice (international)

RRID

AB_2808202

Product Specific Information

Immunogen sequence: LDSKDSDIEQ LRSQLQALHI GLDSSSIGSG PGDAEADDGF PESRLEGWLS LPVRNNTKKF GWVKKYVIVS SKKILFYDSE QDKEQSNPYM VLDIDKLFHV RPVTQTDVYR ADAKEIPRIF QILYANEGES KKEQEFPVEP VGEKSNYICH KGHEFIPTLY HFPTNCEACM KPLWHMFKPP PALECRRCHI KCHKDHMDKK EEIIAPCKVY YDISTAKNLL LLANSTEEQQ KWVSRLVKKI PKKPPAPDPF ARSSPRTSMK IQQNQSIRRP SRQLAPNKPS; Positive Samples: HepG2, HT-29, ES-2, U-937, U-87MG, Mouse lung, Mouse heart; Cellular Location: Cell membrane, Cytoplasm, Nucleus, Peripheral membrane protein, centrosome, cytoskeleton, microtubule organizing center

Target Information

ROCK2, the predominant ROCK isoform in skeletal muscle, is an important regulator downstream of Rho GTPases. ROCK2 regulates cytokinesis, smooth muscle contraction, the formation of actin stress fibers and focal adhesions, and the activation of the c-fos serum response element. This protein, which is an isozyme of ROCK1 is a target for the small GTPase Rho.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: p150 ROK-alpha; p164 ROCK-2; Rho kinase 2; Rho-associated coiled-coil forming kinage 2; Rho-associated coiled-coil forming kinase 2; Rho-associated protein kinase 2; Rho-associated, coiled-coil-containing protein kinase 2; Rho-associated, coiled-coil-containing protein kinase II; RhoA - binding serine/threosine kinase alpha (ROK - alpha); RhoA-binding kinase 2; ROCK II; ROCK-II; rockii; ROKalpha; unnamed protein product

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Gene Aliases: B230113H15Rik; KIAA0619; mKIAA0619; Rho-kinase; ROCK-II; ROCK2; Rock2m; ROK; ROKalpha

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UniProt ID: (Human) O75116, (Rat) Q62868, (Mouse) P70336

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Entrez Gene ID: (Human) 9475, (Rat) 25537, (Mouse) 19878

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Function(s)
nucleotide binding protease binding RNA binding protein kinase activity protein serine/threonine kinase activity structural molecule activity protein binding ATP binding zinc ion binding kinase activity transferase activity small GTPase binding metal ion binding tau protein binding tau-protein kinase activity endopeptidase activator activity Rho-dependent protein serine/threonine kinase activity protein serine kinase activity Rho GTPase binding poly(A) RNA binding transferase activity, transferring phosphorus-containing groups non-receptor serine/threonine protein kinase
Process(es)
mitotic cytokinesis epithelial to mesenchymal transition response to ischemia aortic valve morphogenesis protein phosphorylation smooth muscle contraction signal transduction Rho protein signal transduction positive regulation of cardiac muscle hypertrophy positive regulation of gene expression negative regulation of gene expression positive regulation of centrosome duplication negative regulation of angiogenesis actin cytoskeleton organization regulation of cell adhesion positive regulation of cell migration cortical actin cytoskeleton organization actomyosin structure organization regulation of neurological system process positive regulation of connective tissue growth factor production regulation of actin cytoskeleton organization regulation of circadian rhythm stress fiber assembly positive regulation of MAPK cascade modulation by host of viral process negative regulation of nitric oxide biosynthetic process regulation of keratinocyte differentiation positive regulation of phosphate metabolic process rhythmic process embryonic morphogenesis centrosome duplication regulation of stress fiber assembly positive regulation of stress fiber assembly regulation of focal adhesion assembly mRNA destabilization negative regulation of biomineral tissue development response to transforming growth factor beta protein localization to plasma membrane positive regulation of fibroblast growth factor production regulation of blood vessel diameter regulation of angiotensin-activated signaling pathway negative regulation of protein localization to lysosome regulation of cellular response to hypoxia regulation of cell junction assembly regulation of beta-amyloid formation positive regulation of beta-amyloid formation positive regulation of protein localization to early endosome positive regulation of amyloid precursor protein catabolic process regulation of establishment of endothelial barrier negative regulation of bicellular tight junction assembly cellular response to acetylcholine positive regulation of connective tissue replacement response to angiotensin regulation of establishment of cell polarity regulation of cell motility neural tube closure extrinsic apoptotic signaling pathway via death domain receptors chromosome condensation dendrite morphogenesis phosphorylation intracellular signal transduction
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