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ROM-K Polyclonal Antibody
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Product Details
BS-2960R
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
KLH conjugated synthetic peptide derived from human ROM-K/KCNJ1, amino acids 301-391.
Conjugate
Form
Liquid
Concentration
1 mg/mL
Purification
Protein A
Storage buffer
0.01M TBS, pH 7.4, with 50% glycerol, 1% BSA
Contains
0.02% ProClin 300
Storage conditions
-20°C
Shipping conditions
Ambient (domestic); Wet ice (international)
Target Information
Potassium channels are present in most mammalian cells, where they participate in a wide range of physiologic responses. The protein encoded by this gene is an integral membrane protein and inward-rectifier type potassium channel. It is activated by internal ATP and probably plays an important role in potassium homeostasis. The encoded protein has a greater tendency to allow potassium to flow into a cell rather than out of a cell. Mutations in this gene have been associated with antenatal Bartter syndrome, which is characterized by salt wasting, hypokalemic alkalosis, hypercalciuria, and low blood pressure. Multiple transcript variants encoding different isoforms have been found for this gene.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: ATP-regulated potassium channel ROM-K; ATP-sensitive inward rectifier potassium channel 1; Inward rectifier K(+) channel Kir1.1; inwardly rectifying K+ channel; inwardly rectifying potassium channel ROMK-2; K+ channel protein; KAB-1; kir1.1; OTTHUMP00000045938; Potassium channel, inwardly rectifying subfamily J member 1; Potassium inwardly-rectifying channel subfamily J; potassium inwardly-rectifying channel, subfamily J, member 1; potassium voltage-gated channel subfamily J member 1; unnamed protein product
Gene Aliases: Kcnj; KCNJ1; KIR1.1; ROMK; ROMK1; Romk2
UniProt ID: (Human) P48048, (Mouse) O88335
Entrez Gene ID: (Human) 3758, (Mouse) 56379, (Rat) 24521
nucleotide binding
inward rectifier potassium channel activity
potassium channel activity
ATP binding
phosphatidylinositol-4,5-bisphosphate binding
ATP-activated inward rectifier potassium channel activity
voltage-gated ion channel activity
potassium ion binding
peptide binding
ion channel
transporter
kidney development
tissue homeostasis
ion transport
potassium ion transport
post-embryonic development
gene expression
metal ion transport
ion transmembrane transport
regulation of ion transmembrane transport
renal sodium ion absorption
circulatory system development
potassium ion import across plasma membrane
transport
potassium ion import
negative regulation of apoptotic process
cellular response to magnesium ion
potassium ion transmembrane transport
cardiovascular system development
regulation of G-protein activated inward rectifier potassium channel activity
response to potassium ion
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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