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Invitrogen
ROR gamma Polyclonal Antibody
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FIGURE: 1 / 8
ROR gamma Antibody (PA5-23148) in ICC/IF
Immunocytochemistry analysis of ROR gamma in U-2 OS cells. Samples were incubated with ROR gamma polyclonal antibody (Product # PA5-23148) followed by anti-rabbit Dylight 488 (Green). Cells were fixed for 10 minutes using 10% formalin and then permeabilized for 5 minutes using 1X TBS + 0.5% Triton-X100. Alpha tubulin (DM1A) was used as a co-stain and detected with an anti-mouse Dylight 550 (Red). Nuclei wer... View More
Product Details
PA5-23148
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse
Published species
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
A portion of amino acids 1-50 of human ROR gamma/RORC/NR1F3.
Conjugate
Form
Liquid
Concentration
1 mg/mL
Amount
100 µg
Purification
Antigen affinity chromatography
Storage buffer
PBS
Contains
0.02% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
The amino acid sequence used as immunogen Porcine, Rat (81%).
Target Information
ROR gamma is a 560 amino acid novel DNA-binding transcription factor belonging to the ROR/RZR orphan nuclear receptor subfamily. Reports suggest thatROR gammais a ligand activated transcription factor and may be essential for lymphoid organogenesis (lymph nodes and Peyer's patches) and may play an important regulatory role in controlling apoptosis during thymopoiesis. ROR gamma inhibits the expression of Fas ligand and IL2 and directs the differentiation program of proinflammatory IL-17+ T helper cells. ROR gamma shares 50 to 51% sequence identity with RORA and RORB and is 88% identical to mouse ROR gamma. It is highly expressed in skeletal muscle and at lower levels in various other tissues.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: Nuclear receptor ROR-gamma; Nuclear receptor RZR-gamma; Nuclear receptor subfamily 1 group F member 3; RAR-related orphan receptor C; retinoic acid-binding receptor gamma; retinoid-related orphan receptor gamma; Retinoid-related orphan receptor-gamma; RORC; Thymus orphan receptor; TOR; unnamed protein product
Gene Aliases: IMD42; NR1F3; RORC; RORG; RORgamma; RZR-GAMMA; RZRG; Thor; TOR
UniProt ID: (Human) P51449, (Mouse) P51450
Entrez Gene ID: (Human) 6097, (Mouse) 19885
RNA polymerase II core promoter proximal region sequence-specific DNA binding
RNA polymerase II transcription factor activity, sequence-specific DNA binding
transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding
DNA binding
transcription factor activity, sequence-specific DNA binding
RNA polymerase II transcription factor activity, ligand-activated sequence-specific DNA binding
protein binding
oxysterol binding
zinc ion binding
sequence-specific DNA binding
metal ion binding
transcription factor activity, direct ligand regulated sequence-specific DNA binding
sequence-specific double-stranded DNA binding
transcription coactivator binding
steroid hormone receptor activity
C4 zinc finger nuclear receptor
negative regulation of transcription from RNA polymerase II promoter
regulation of transcription, DNA-templated
regulation of transcription from RNA polymerase II promoter
xenobiotic metabolic process
circadian rhythm
regulation of gene expression
regulation of glucose metabolic process
regulation of steroid metabolic process
intracellular receptor signaling pathway
circadian regulation of gene expression
cellular response to sterol
T-helper cell differentiation
positive regulation of circadian rhythm
regulation of fat cell differentiation
positive regulation of transcription, DNA-templated
rhythmic process
lymph node development
Peyer's patch development
adipose tissue development
negative regulation of thymocyte apoptotic process
T-helper 17 cell differentiation
transcription, DNA-templated
protein phosphorylation
multicellular organism development
cell differentiation
interleukin-17 production
T cell differentiation in thymus
steroid hormone mediated signaling pathway
regulation of gamma-delta T cell differentiation
alpha-beta T cell differentiation
mucosal-associated lymphoid tissue development
regulation of transcription involved in cell fate commitment
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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