Proteintech

RORA Polyclonal Antibody

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RORA Antibody in Western Blot (WB) — Mouse kidney tissue were subjected to SDS PAGE followed by western blot with 10616-1-AP (RORA antibody) at dilution of 1:1000 incubated at room temperature for 1.5 hours.

RORA Antibody in Western Blot (WB) — Mouse liver tissue were subjected to SDS PAGE followed by western blot with 10616-1-AP (RORA antibody) at dilution of 1:1000 incubated at room temperature for 1.5 hours.

RORA Antibody in Western Blot (WB) — Mouse liver tissue were subjected to SDS PAGE followed by western blot with 10616-1-AP (RORA antibody) at dilution of 1:1000 incubated at room temperature for 1.5 hours.

RORA Antibody in Western Blot (WB) — Rat liver tissue were subjected to SDS PAGE followed by western blot with 10616-1-AP (RORA Antibody) at dilution of 1:1000 incubated at room temperature for 1.5 hours.

RORA Antibody in Western Blot (WB) — Jurkat cells were subjected to SDS PAGE followed by western blot with 10616-1-AP (RORA antibody) at dilution of 1:200 incubated at room temperature for 1.5 hours.

RORA Antibody in Western Blot (WB) — K-562 cells were subjected to SDS PAGE followed by western blot with 10616-1-AP (RORA antibody) at dilution of 1:1000 incubated at room temperature for 1.5 hours.

RORA Antibody in Western Blot (WB) — HeLa cells were subjected to SDS PAGE followed by western blot with 10616-1-AP (RORA antibody) at dilution of 1:1000 incubated at room temperature for 1.5 hours.

RORA Antibody in Western Blot (WB) — HeLa cells were subjected to SDS PAGE followed by western blot with 10616-1-AP (RORA antibody) at dilution of 1:1000 incubated at room temperature for 1.5 hours.

RORA Antibody in Western Blot (WB) — HeLa cells were subjected to SDS PAGE followed by western blot with 10616-1-AP (RORA antibody) at dilution of 1:1000 incubated at room temperature for 1.5 hours.

RORA Antibody in Western Blot (WB) — PC-3 cells were subjected to SDS PAGE followed by western blot with 10616-1-AP (RORA antibody) at dilution of 1:1000 incubated at room temperature for 1.5 hours.

RORA Antibody in Western Blot (WB) — HeLa cells were subjected to SDS PAGE followed by western blot with 10616-1-AP (RORA antibody) at dilution of 1:1000 incubated at room temperature for 1.5 hours.

Product Details

10616-1-AP

Applications

Tested Dilution

Publications

Western Blot (WB)

1:500-1:2,000

View 14 publications 14 publications

Immunohistochemistry (IHC)

-

View 1 publication 1 publication

Immunoprecipitation (IP)

-

View 1 publication 1 publication

Product Specifications

Species Reactivity

Human, Mouse, Rat

Published species

Human, Mouse, Rat

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

RORA Fusion Protein Ag0944 (223-523 aa encoded by BC008831)

Conjugate

Unconjugated

Form

Liquid

Concentration

0.25 mg/mL

Purification

Antigen affinity chromatography

Storage buffer

PBS, pH 7.3, with 50% glycerol

Contains

0.02% sodium azide

Storage conditions

-20°C

Product Specific Information

Immunogen sequence: LDIQPSPDQ SGLDINGIKP EPICDYTPAS GFFPYCSFTN GETSPTVSMA ELEHLAQNIS KSHLETCQYL REELQQITWQ TFLQEEIENY QNKQREVMWQ LCAIKITEAI QYVVEFAKRI DGFMELCQND QIVLLKAGSL EVVFIRMCRA FDSQNNTVYF DGKYASPDVF KSLGCEDFIS FVFEFGKSLC SMHLTEDEIA LFSAFVLMSA DRSWLQEKVK IEKLQQKIQL ALQHVLQKNH REDGILTKLI CKVSTLRALC GRHTEKLMAF KAIYPDIVRL HFPPLYKELF TSEFEPAMQI DG (223-523 aa encoded by BC008831)

Target Information

RORA is a receptor for retinoic acid belonging to the NR1 subfamily of nuclear hormone receptors with a nuclear receptor DNA binding domain. RORA binds either as a monomer or as a homodimer to the retinoic acid response element and thus regulates gene expression and also controls cell function. Though the exact function of RORA is yet unknown, it interacts with NM23-2, a nucleoside diphosphate kinase involved in organogenesis and differentiation, NM23-1, the product of a tumor metastasis suppressor candidate gene, CDK7, NCOA3 and NCOA6 coactivators. It is found to express in mesenchymal stem cells derived from bone marrow and are known to act by direct modulation of a bone matrix component. It is widely expressed in most of the tissues. Chromosomal aberrations involving RORA may be a cause of acute promyelocytic leukemia (APL).

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

Product References

MicroRNA-155 suppressed cholesterol-induced matrix degradation, pyroptosis and apoptosis by targeting RORα in nucleus pulposus cells.

Cellular signalling

Qin T,Yan J,Li S,Lin X,Wu J,Huang Z,Zhang C,Zhang Y,Deng Z,Xiao D,Jin S,Xiao Y,Xu K,Ye W

Sat Jul 01 00:00:00 EDT 2023

MicroRNA-155 suppressed cholesterol-induced matrix degradation, pyroptosis and apoptosis by targeting RORα in nucleus pulposus cells.

Cellular signalling

Qin T,Yan J,Li S,Lin X,Wu J,Huang Z,Zhang C,Zhang Y,Deng Z,Xiao D,Jin S,Xiao Y,Xu K,Ye W

Sat Jul 01 00:00:00 EDT 2023

MicroRNA-155 suppressed cholesterol-induced matrix degradation, pyroptosis and apoptosis by targeting RORα in nucleus pulposus cells.

Cellular signalling

Qin T,Yan J,Li S,Lin X,Wu J,Huang Z,Zhang C,Zhang Y,Deng Z,Xiao D,Jin S,Xiao Y,Xu K,Ye W

Sat Jul 01 00:00:00 EDT 2023

MicroRNA-155 suppressed cholesterol-induced matrix degradation, pyroptosis and apoptosis by targeting RORα in nucleus pulposus cells.

Cellular signalling

Qin T,Yan J,Li S,Lin X,Wu J,Huang Z,Zhang C,Zhang Y,Deng Z,Xiao D,Jin S,Xiao Y,Xu K,Ye W

Sat Jul 01 00:00:00 EDT 2023

MicroRNA-155 suppressed cholesterol-induced matrix degradation, pyroptosis and apoptosis by targeting RORα in nucleus pulposus cells.

Cellular signalling

Qin T,Yan J,Li S,Lin X,Wu J,Huang Z,Zhang C,Zhang Y,Deng Z,Xiao D,Jin S,Xiao Y,Xu K,Ye W

Sat Jul 01 00:00:00 EDT 2023

MicroRNA-155 suppressed cholesterol-induced matrix degradation, pyroptosis and apoptosis by targeting RORα in nucleus pulposus cells.

Cellular signalling

Qin T,Yan J,Li S,Lin X,Wu J,Huang Z,Zhang C,Zhang Y,Deng Z,Xiao D,Jin S,Xiao Y,Xu K,Ye W

Sat Jul 01 00:00:00 EDT 2023

POU6F1 cooperates with RORA to suppress the proliferation of lung adenocarcinoma by downregulation HIF1A signaling pathway.

Cell death & disease

Xiao W,Geng W,Zhou M,Xu J,Wang S,Huang Q,Sun Y,Li Y,Yang G,Jin Y

Tue May 03 00:00:00 EDT 2022

POU6F1 cooperates with RORA to suppress the proliferation of lung adenocarcinoma by downregulation HIF1A signaling pathway.

Cell death & disease

Xiao W,Geng W,Zhou M,Xu J,Wang S,Huang Q,Sun Y,Li Y,Yang G,Jin Y

Tue May 03 00:00:00 EDT 2022

ROR2 receptor promotes the migration of osteosarcoma cells in response to Wnt5a.

Cancer cell international

Dai B,Yan T,Zhang A

Fri Mar 11 00:00:00 EST 2022

ROR2 receptor promotes the migration of osteosarcoma cells in response to Wnt5a.

Cancer cell international

Dai B,Yan T,Zhang A

Fri Mar 11 00:00:00 EST 2022

ILC2s induce adaptive Th2-type immunity in different stages of tuberculosis through the Notch-GATA3 pathway.

International immunopharmacology

Li Q,Zhang J,Ma L,Wu C,Zhao J,Guan W,Li X,Yang X,Wen F

Wed Dec 01 00:00:00 EST 2021

Circadian oscillation expression of ornithine carbamoyltransferase and its significance in sleep disturbance.

Biochemical and biophysical research communications

Wang W,Zhang Y,Ding M,Huang X,Zhang M,Gu Y,Wu L,Zhang C,Lu C,Shen B,Xing C,Song L

Fri Jun 25 00:00:00 EDT 2021

Hydrogen peroxide modulates clock gene expression via PRX2-STAT3-REV-ERBα/β pathway.

Free radical biology & medicine

Ji G,Lv K,Chen H,Wang Y,Zhang Y,Li Y,Qu L

Sun Dec 01 00:00:00 EST 2019

MCPIP1 regulates RORα expression to protect against liver injury induced by lipopolysaccharide via modulation of miR-155.

Journal of cellular physiology

Li Z,Han S,Jia Y,Yang Y,Han F,Wu G,Li X,Zhang W,Jia W,He X,Han J,Hu D

Sun Sep 01 00:00:00 EDT 2019

ROR alpha protects against LPS-induced inflammation by down-regulating SIRT1/NF-kappa B pathway.

Archives of biochemistry and biophysics

Han S,Li Z,Han F,Jia Y,Qi L,Wu G,Cai W,Xu Y,Li C,Zhang W,Hu D

Sat Jun 15 00:00:00 EDT 2019

lncRNA 430945 promotes the proliferation and migration of vascular smooth muscle cells via the ROR2/RhoA signaling pathway in atherosclerosis.

Molecular medicine reports

Cui C,Wang X,Shang XM,Li L,Ma Y,Zhao GY,Song YX,Geng XB,Zhao BQ,Tian MR,Wang HL

Sat Jun 01 00:00:00 EDT 2019

Loss of circadian protein TIMELESS accelerates the progression of cellular senescence.

Biochemical and biophysical research communications

Shen X,Li M,Mao Z,Yu W

Tue Sep 18 00:00:00 EDT 2018

Loss of circadian protein TIMELESS accelerates the progression of cellular senescence.

Biochemical and biophysical research communications

Shen X,Li M,Mao Z,Yu W

Tue Sep 18 00:00:00 EDT 2018

A proteomics landscape of circadian clock in mouse liver.

Nature communications

Wang Y,Song L,Liu M,Ge R,Zhou Q,Liu W,Li R,Qie J,Zhen B,Wang Y,He F,Qin J,Ding C

Thu Apr 19 00:00:00 EDT 2018

A proteomics landscape of circadian clock in mouse liver.

Nature communications

Wang Y,Song L,Liu M,Ge R,Zhou Q,Liu W,Li R,Qie J,Zhen B,Wang Y,He F,Qin J,Ding C

Thu Apr 19 00:00:00 EDT 2018

Maternal melatonin or agomelatine therapy prevents programmed hypertension in male offspring of mother exposed to continuous light.

Biology of reproduction

Tain YL,Lin YJ,Chan JYH,Lee CT,Hsu CN

Sun Oct 01 00:00:00 EDT 2017

Maternal melatonin or agomelatine therapy prevents programmed hypertension in male offspring of mother exposed to continuous light.

Biology of reproduction

Tain YL,Lin YJ,Chan JYH,Lee CT,Hsu CN

Sun Oct 01 00:00:00 EDT 2017

Postnatal dexamethasone-induced programmed hypertension is related to the regulation of melatonin and its receptors.

Steroids

Chang HY,Tain YL

Fri Apr 01 00:00:00 EDT 2016

Postnatal dexamethasone-induced programmed hypertension is related to the regulation of melatonin and its receptors.

Steroids

Chang HY,Tain YL

Fri Apr 01 00:00:00 EDT 2016

Maternal Melatonin Therapy Rescues Prenatal Dexamethasone and Postnatal High-Fat Diet Induced Programmed Hypertension in Male Rat Offspring.

Frontiers in physiology

Tain YL,Sheen JM,Yu HR,Chen CC,Tiao MM,Hsu CN,Lin YJ,Kuo KC,Huang LT

Wed Dec 23 00:00:00 EST 2015

Maternal Melatonin Therapy Rescues Prenatal Dexamethasone and Postnatal High-Fat Diet Induced Programmed Hypertension in Male Rat Offspring.

Frontiers in physiology

Tain YL,Sheen JM,Yu HR,Chen CC,Tiao MM,Hsu CN,Lin YJ,Kuo KC,Huang LT

Wed Dec 23 00:00:00 EST 2015

Bioinformatics

Protein Aliases: Nuclear receptor ROR-alpha; Nuclear receptor RZR-alpha; Nuclear receptor subfamily 1 group F member 1; RAR-related orphan receptor A; RAR-related orphan receptor alpha; retinoic acid receptor-related orphan receptor alpha; retinoid-related orphan receptor alpha; Retinoid-related orphan receptor-alpha; ROR Alpha; ROR-alpha; Roralpha; thyroid hormone nuclear receptor alpha variant 4; transcription factor RZR-alpha

Gene Aliases: 9530021D13Rik; nmf267; NR1F1; ROR1; ROR2; ROR3; RORA; RZR-ALPHA; RZRA; sg; staggerer; tmgc26

UniProt ID: (Human) P35398, (Mouse) P51448

Entrez Gene ID: (Human) 6095, (Rat) 300807, (Mouse) 19883

Molecular Function: C4 zinc finger nuclear receptor

angiogenesis regulation of transcription, DNA-templated transcription initiation from RNA polymerase II promoter xenobiotic metabolic process nitric oxide biosynthetic process regulation of smoothened signaling pathway positive regulation of vascular endothelial growth factor production regulation of glucose metabolic process regulation of steroid metabolic process cerebellar Purkinje cell differentiation cerebellar granule cell precursor proliferation intracellular receptor signaling pathway circadian regulation of gene expression cellular response to sterol muscle cell differentiation positive regulation of circadian rhythm regulation of macrophage activation negative regulation of I-kappaB kinase/NF-kappaB signaling steroid hormone mediated signaling pathway negative regulation of fat cell differentiation positive regulation of transcription, DNA-templated positive regulation of transcription from RNA polymerase II promoter cGMP metabolic process negative regulation of inflammatory response regulation of transcription involved in cell fate commitment triglyceride homeostasis cellular response to interleukin-1 cellular response to tumor necrosis factor cellular response to hypoxia T-helper 17 cell differentiation regulation of cholesterol homeostasis transcription, DNA-templated circadian rhythm regulation of circadian rhythm rhythmic process

Process(es)

RNA polymerase II regulatory region sequence-specific DNA binding core promoter sequence-specific DNA binding transcription corepressor binding transcription coactivator binding DNA binding transcription factor activity, sequence-specific DNA binding steroid hormone receptor activity RNA polymerase II transcription factor activity, ligand-activated sequence-specific DNA binding protein binding beta-catenin binding transcription factor binding oxysterol binding zinc ion binding sequence-specific DNA binding transcription factor activity, direct ligand regulated sequence-specific DNA binding metal ion binding