PA1-812 detects human ROR alpha protein in transfected cell samples. PA1-812 is specific for alpha isotypes.
PA1-812 has successfully been used in Western blot procedures. By Western blot, this antibody detects an ~56 kDa protein representing ROR alpha in transfected BL21 cells using a pGEX-hROR alpha1-GST vector.
The PA1-812 immunogen is a synthetic peptide corresponding to residues K(541) E L F T S E F E P A M Q I D G(556) of human ROR alpha. This peptide (Cat. # PEP-230) is available for use in neutralization and control experiments.
The retinoic acid receptor-related orphan receptor alpha (ROR alpha), also known as RZRa, is a member of structurally related, nuclear receptor superfamily. To date, ROR alpha, beta, and gamma subtypes have been discovered and within the ROR alpha group there are ROR alpha 1, 2, 3, and 4. ROR isotypes have been shown to differ in only their amino terminus.
Research has shown that these proteins are key in regulation of many physiological processes such as cell growth and differentiation. ROR alpha is also critical for proper cerebellar development, modulation of gene expression in response to hypoxic stress, and migratory capacities of cancer cells.
The corresponding gene for the ROR alpha is NR1F1.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: NR1F1; Nuclear receptor ROR-alpha; Nuclear receptor RZR-alpha; Nuclear receptor subfamily 1 group F member 1; RAR-related orphan receptor A; Retinoic Acid Receptor-Related Orphan Receptor Alpha; retinoid-related orphan receptor alpha; Retinoid-related orphan receptor-alpha; ROR-alpha; ROR3; RZR-Alpha; thyroid hormone nuclear receptor alpha variant 4; transcription factor RZR-alpha
Gene Aliases: NR1F1; ROR1; ROR2; ROR3; RORA; RZR-ALPHA; RZRA
UniProt ID: (Human) P35398
Entrez Gene ID: (Human) 6095