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Product Details
PA5-28742
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Synthetic peptide corresponding to a region within amino acids 2 and 45 of ROR beta
Conjugate
Form
Liquid
Concentration
1 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
0.1M tris glycine, pH 7, with 10% glycerol
Contains
0.01% thimerosal
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Wet ice
RRID
AB_2546218
Product Specific Information
Recommended positive controls: HeLa, HepG2, Molt-4, mouse brain.^M
^M
Predicted reactivity: Mouse (100%), Rat (100%), Zebrafish (100%), Chicken (100%), Sheep (100%), Rhesus Monkey (100%), Bovine (100%).^M
^M
Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.
Target Information
Retinoid-related orphan receptor beta (ROR beta), a NR1 thyroid hormone receptor, affects the development and functioning of the central nervous system, including sensory input integration and circadian timing. Disruption of ROR beta in mice results in juvenile ataxia, retinal degeneration, circadian activity abnormalities, and delayed onset of male fertility. ROR beta binds to the monomeric response elements containing the sequence AnnTAGGTCA as a monomer. An alternatively spliced isoform, ROR beta2, has been isolated from rats, and the expression of ROR beta2 is confined to the pineal gland and retina. ROR beta2 shares common DNA- and putative ligand-binding domains with wild-type ROR beta but is characterized by a different amino-terminal domain. ROR beta expression has been documented in various regions of the mouse brain.
⚠WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm. For more information go to www.P65Warnings.ca.gov.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: Nuclear receptor ROR-beta; Nuclear receptor RZR-beta; Nuclear receptor subfamily 1 group F member 2; RAR-related orphan receptor B; RAR-related orphan receptor beta; retinoic acid-binding receptor beta; retinoid-related orphan receptor beta; Retinoid-related orphan receptor-beta
Gene Aliases: bA133M9.1; NR1F2; ROR-BETA; Rorb; Rorbeta; RZR-BETA; RZRB
UniProt ID: (Mouse) Q8R1B8
Entrez Gene ID: (Human) 6096, (Mouse) 225998
transcription factor activity, sequence-specific DNA binding
steroid hormone receptor activity
RNA polymerase II transcription factor activity, ligand-activated sequence-specific DNA binding
protein binding
transcription factor binding
zinc ion binding
melatonin receptor activity
sequence-specific DNA binding
DNA binding
metal ion binding
C4 zinc finger nuclear receptor
regulation of transcription, DNA-templated
transcription initiation from RNA polymerase II promoter
G-protein coupled receptor signaling pathway
brain development
visual perception
circadian rhythm
intracellular receptor signaling pathway
amacrine cell differentiation
eye photoreceptor cell development
regulation of circadian rhythm
steroid hormone mediated signaling pathway
negative regulation of osteoblast differentiation
negative regulation of transcription, DNA-templated
positive regulation of transcription, DNA-templated
retinal rod cell development
retinal cone cell development
retina development in camera-type eye
cellular response to retinoic acid
transcription, DNA-templated
multicellular organism development
rhythmic process
response to stimulus
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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