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Proteintech
RORC Polyclonal Antibody
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Product Details
13205-1-AP
Applications
Tested Dilution
Publications
Product Specifications
Published species
Human,
Mouse
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
RORC Fusion Protein Ag3961 (165-518 aa encoded by BC031554)
Conjugate
Form
Liquid
Concentration
0.15 mg/mL
Storage conditions
-20°C
Shipping conditions
Wet ice (domestic); Dry ice (international)
Product Specific Information
Immunogen sequence: DLPEASACP PGLLKASGSG PSYSNNLAKA GLNGASCHLE YSPERGKAEG RESFYSTGSQ LTPDRCGLRF EEHRHPGLGE LGQGPDSYGS PSFRSTPEAP YASLTEIEHL VQSVCKSYRE TCQLRLEDLL RQRSNIFSRE EVTGYQRKSM WEMWERCAHH LTEAIQYVVE FAKRLSGFME LCQNDQIVLL KAGAMEVVLV RMCRAYNADN RTVFFEGKYG GMELFRALGC SELISSIFDF SHSLSALHFS EDEIALYTAL VLINAHRPGL QEKRKVEQLQ YNLELAFHHH LCKTHRQSIL AKLPPKGKLR SLCSQHVERL QIFQHLHPIV VQAAFPPLYK ELFSTETESP VGLSK (165-518 aa encoded by BC031554)
Target Information
ROR gamma is a 560 amino acid novel DNA-binding transcription factor belonging to the ROR/RZR orphan nuclear receptor subfamily. Reports suggest thatROR gammais a ligand activated transcription factor and may be essential for lymphoid organogenesis (lymph nodes and Peyer's patches) and may play an important regulatory role in controlling apoptosis during thymopoiesis. ROR gamma inhibits the expression of Fas ligand and IL2 and directs the differentiation program of proinflammatory IL-17+ T helper cells. ROR gamma shares 50 to 51% sequence identity with RORA and RORB and is 88% identical to mouse ROR gamma. It is highly expressed in skeletal muscle and at lower levels in various other tissues.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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