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Invitrogen
Human MMP-14 (Prodomain-catalytic domain-hemopexin domain) His-tag Recombinant Protein
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Product Details
RP-77533
Product Specifications
Expression System
E. coli
Class
Recombinant
Type
Protein
Conjugate
Form
Liquid
Concentration
0.2 mg/mL
Amount
10 µg
Storage conditions
-80°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Dry ice
Product Specific Information
RP-77533 is a purified His-tagged recombinant MT1-MMP/MMP-14 protein (prodomain, catalytic domain, and hemopexin domain) expressed in E.coli. RP-77533 may be used as a control with corresponding anti-MMP-14 antibodies. The pro-enzyme can be activated with trace amounts of the MT1-MMP catalytic domain.
Target Information
Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. Most MMP's are secreted as inactive proproteins which are activated when cleaved by extracellular proteinases. However, the protein encoded by this gene is a member of the membrane-type MMP (MT-MMP) subfamily; each member of this subfamily contains a potential transmembrane domain suggesting that these proteins are expressed at the cell surface rather than secreted. This protein activates MMP2 protein, and this activity may be involved in tumor invasion.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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