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Invitrogen
Human HTRA1 Recombinant Protein
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FIGURE: 1 / 2
Human HTRA1 Protein (RP-77538)
Hydrolysis of beta-Casein by HtrA1 (Product # RP-77538). Beta-Casein (0.5 mg/mL) was incubated in 50 mM Tris-HCl, pH 7.5, 150 mM NaCl, 5 mM CaCl2 without or with HtrA1 (5 µg/mL). After various time intervals aliquots of the reaction mixtures were withdrawn and analyzed by SDS-PAGE.
Product Details
RP-77538
Product Specifications
Expression System
Insect cells
Class
Recombinant
Type
Protein
Conjugate
Form
Liquid
Concentration
0.2 mg/mL
Amount
5 µg
Storage conditions
-80°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Wet ice
Product Specific Information
RP-77538 may be used in inhibition assays and as a control with corresponding anti-HtrA1 antibodies.
Target Information
HtrA1, a 51KDa protein, is a member of highly conserved mammalian HtrA serine protease family. It is a human homolog of bacterial HtrA and consists of a secretory signal sequence, an IGFBP-binding domain and a Kazal-type serine-protease inhibitor domain at the N-terminus and a highly conserved trypsin-like serine/protease domain and a PDZ domain at the C-terminus. It plays a major role in the regulation of cell growth. HtrA1 inhibits signaling mediated by TGF-beta family members and regulates many physiological processes. HtrA1 is up-regulated in placenta during pregnancy and plays an important role in implantation and placental physiology. It regulates the availability of IGFs by cleaving IGF-binding proteins. It acts as a tumor suppressor and is down-regulated in ovarian cancers and melanomas. Its role has been implicated in osteoarthritis suggesting a therapeutic intervention. Northern blot analysis detected high expression in placenta.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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