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Invitrogen
RPE65 Polyclonal Antibody
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Product Details
PA5-78414
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse
Published species
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant protein encompassing a sequence within the center region of human RPE65. The exact sequence is proprietary.
Conjugate
Form
Liquid
Concentration
0.96 mg/mL
Amount
96 µg
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7, with 20% glycerol
Contains
0.025% ProClin 300
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Positive Control: mouse eye
Predicted Reactivity: Rat (93%), Xenopus laevis (83%), Dog (97%), Chicken (89%), Bovine (98%)
Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.
Target Information
RPE65 is a major protein of the retinal pigment epithelium (RPE). RPE65 is essential for the regeneration of rhodopsin in the visual cycle. Mutations in RPE65 are responsible for certain forms of autosomal recessive severe retinal dystrophy, including Leber Congenital Amaurosis (LCA). Loss of function results in a block in retinoid processing required for the synthesis of 11-cis retinal and the accumulation of retinyl esters in the RPE.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: All-trans-retinyl-palmitate hydrolase; BCO family, member 3; Lutein isomerase; Meso-zeaxanthin isomerase; modifier of retinal degeneration 1; RBP-binding membrane protein; retinal pigment epithelium specific protein 65; retinal pigment epithelium, 65 kDa; Retinal pigment epithelium-specific 65 kDa protein; retinal pigment epithelium-specific protein 65kDa; Retinitis pigmentos; retinitis pigmentosa 20 (autosomal recessive); Retinoid isomerohydrolase; Retinol isomerase; RPE65, retinoid isomerohydrolase; unnamed protein product
Gene Aliases: 65kDa; A930029L06Rik; BCO3; LCA2; Mord1; mRPE65; p63; rd12; RP20; RPE65; sRPE65
UniProt ID: (Human) Q16518, (Mouse) Q91ZQ5
Entrez Gene ID: (Human) 6121, (Mouse) 19892
phosphatidylserine binding
beta-carotene 15,15'-monooxygenase activity
protein binding
oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen
hydrolase activity
isomerase activity
phosphatidylcholine binding
metal ion binding
retinol isomerase activity
all-trans-retinyl-palmitate hydrolase, 11-cis retinol forming activity
all-trans-retinyl-ester hydrolase, 11-cis retinol forming activity
cardiolipin binding
retinal isomerase activity
oxygenase
retinoid metabolic process
retina homeostasis
neural retina development
lipid metabolic process
vitamin A metabolic process
visual perception
circadian rhythm
response to light stimulus
retinol metabolic process
retinal metabolic process
camera-type eye development
detection of light stimulus involved in visual perception
zeaxanthin biosynthetic process
regulation of rhodopsin gene expression
insulin receptor signaling pathway
response to stimulus
retina development in camera-type eye
retina morphogenesis in camera-type eye
cellular response to electrical stimulus
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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