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RPL23 Polyclonal Antibody
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FIGURE: 1 / 2
RPL23 Antibody (PA5-101385) in IHC (P)
Immunohistochemistry analysis of paraffin-embedded RPL23 in rat spleen tissue. Antigen retrieval was performed using citrate buffer. Samples were blocked with blocking buffer (1.5 hr, 22°C), incubated with RPL23 polyclonal antibody (Product # PA5-101385) using a dilution of 1:100 (1.5 hr, 22°C), followed by HRP conjugated goat anti-rabbit.
Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
Product Details
PA5-101385
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
A synthesized peptide derived from human RPL23, corresponding to a region within C-terminal amino acids.
Conjugate
Unconjugated
Unconjugated
Unconjugated
Form
Liquid
Concentration
1 mg/mL
Amount
100 µg
Purification
Affinity chromatography
Storage buffer
PBS, pH 7.4, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Antibody detects endogenous levels of total RPL23.
Target Information
This gene encodes a ubiquitously expressed nuclear protein which belongs to a highly conserved subfamily of WD-repeat proteins. It is present in protein complexes involved in histone acetylation and chromatin assembly. It is part of the Mi-2 complex which has been implicated in chromatin remodeling and transcriptional repression associated with histone deacetylation. This encoded protein is also part of co-repressor complexes, which is an integral component of transcriptional silencing. It is found among several cellular proteins that bind directly to retinoblastoma protein to regulate cell proliferation. This protein also seems to be involved in transcriptional repression of E2F-responsive genes. Three transcript variants encoding different isoforms have been found for this gene.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: 60S ribosomal protein L17; 60S ribosomal protein L23; MGC111167; MGC117346; MGC72008; ribosomal protein L17; unnamed protein product
Gene Aliases: 2810009A01Rik; L23; RL23a; rpL17; uL14
UniProt ID: (Human) P62829, (Mouse) P62830, (Rat) P62832
Entrez Gene ID: (Human) 9349, (Mouse) 65019, (Rat) 29282
negative regulation of transcription from RNA polymerase II promoter
cytoplasmic translation
translation
striated muscle contraction
spermatogenesis
positive regulation of cell proliferation
positive regulation of gene expression
protein-DNA complex disassembly
protein stabilization
G1 to G0 transition
cellular response to actinomycin D
translation at presynapse
translation at postsynapse
negative regulation of myoblast fusion
positive regulation of signal transduction by p53 class mediator
regulation of G1 to G0 transition
negative regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process
ribosomal protein import into nucleus
biological_process
Disclaimer
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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