WD repeat domain 5 (WDR5) is a member of the WD repeat protein family, which is involved in a variety of cellular processes, including cell cycle progression, signal transduction, apoptosis, and gene regulation. WDR5, also known as BIG-3, is expressed in the developing growth plate, accelerates chondrocyte and osteoblast differentiation in vitro, and regulates osteoblast differentiation during embryonic bone development. WDR5 interacts with the pluripotency factor Oct4/POU5F1 and is required for the efficient formation of induced pluripotent stem (iPS) cells.
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Protein Aliases: 40S ribosomal protein S3; IMR-90 ribosomal protein S3; ribosomal protein S3; RPS3; Small ribosomal subunit protein uS3
Gene Aliases: D7Ertd795e; OK/SW-cl.26; RPS3; Rs_3; S3