This Antibody was verified by KnockDown to ensure that the antibody binds to the antigen stated. View Details
PA5-27974 targets RPS3 in IF, IHC (P), and WB applications and shows reactivity with Human, Rat and mouse samples.
The PA5-27974 immunogen is recombinant fragment corresponding to a region within amino acids 1 and 243 of Human RPS3.
Store product as a concentrated solution. Centrifuge briefly prior to opening the vial. For short-term storage (1-2 weeks), product can be stored at 4°C. For long-term storage, aliquot and store product at -20° C or below, avioiding multiple freeze-thaw cycles.
Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a ribosomal protein that is a component of the 40S subunit, where it forms part of the domain where translation is initiated. The protein belongs to the S3P family of ribosomal proteins. Studies of the mouse and rat proteins have demonstrated that the protein has an extraribosomal role as an endonuclease involved in the repair of UV-induced DNA damage. The protein appears to be located in both the cytoplasm and nucleus but not in the nucleolus. Higher levels of expression of this gene in colon adenocarcinomas and adenomatous polyps compared to adjacent normal colonic mucosa have been observed. This gene is co-transcribed with the small nucleolar RNA genes U15A and U15B, which are located in its first and fifth introns, respectively. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome.
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Protein Aliases: 40S ribosomal protein S3; IMR-90 ribosomal protein S3; S3; Small ribosomal subunit protein uS3
Gene Aliases: D7Ertd795e; OK/SW-cl.26; RPS3; Rs_3; S3