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Immunogen sequence: VGKSALARIF GGVEDGPEAE AAGHTYDRSI VVDGEEASLM VYDIWEQDGG RWLPGHCMAM GDAYVIVYSV TDK
Highest antigen sequence identity to the following orthologs: Mouse - 93%, Rat - 95%.
The Ras-encoded family of proteins bind GDP and GTP with high affinity. They possess a low level of intrinsic GTPase activity that increases more than 100-fold when interacting with cytosolic GTPase activating protein (GAP). Ras family members include H-Ras, K-Ras, N-Ras, M-Ras, R-Ras, ERas, Rheb, TC 21, RASL11B and Rad (Ras associated with diabetes) GTPase.Rad GTPase is a GTP-binding protein that is similar to Ras but has unique features. Unlike other small GTPases, Rad GTPase lacks typical pren-ylation motifs at its C terminus. The Rad GTPase enzyme binds calmodulin, inhibits vascular lesion formation, has low intrinsic GTPase activity and cannot be stimulated by any known GAP molecules. Rad GTPase is expressed in skeletal muscle, cardiac muscle and lung tissues and is overexpressed in the skeletal muscle tissue of individuals with type II diabetes.
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Protein Aliases: GTP-binding protein RAD; RAD1; RAS (RAD and GEM) like GTP binding 3; Ras associated with diabetes; Ras-related associated with diabetes; RRAD, Ras related glycolysis inihibitor and calcium channel regulator
Gene Aliases: RAD; RAD1; REM3; RRAD
UniProt ID: (Human) P55042
Entrez Gene ID: (Human) 6236