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Bioss
RRAGC Polyclonal Antibody
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Product Details
BS-10097R
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
KLH conjugated synthetic peptide derived from human RRAGC, amino acids 301-399.
Conjugate
Form
Liquid
Concentration
1 mg/mL
Purification
Protein A
Storage buffer
0.01M TBS, pH 7.4, with 50% glycerol, 1% BSA
Contains
0.02% ProClin 300
Storage conditions
-20°C
Shipping conditions
Ambient (domestic); Wet ice (international)
Target Information
RRAGC (Ras-related GTP-binding protein C) is a monomeric guanine nucleotide-binding protein that plays a crucial role in the cellular response to amino acid availability through regulations of the mTORC1 signaling cascade. RRAGC forms a heterodimer with RRAGA and RRAGB and is primarily localized to the cytoplasm. It cycles between an inactive GTP-bound and an active GDP-bound form. RRAGC, in its active form, participates in the re-localization of mTORC1 to the lysosomes and its subsequent activation by the GTPase RHEB. This re-localization is a crucial step in the activation of the TOR signaling cascade by amino acids.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: GTPase-interacting protein 2; Rag C; Rag C protein; Ras-related GTP binding C; Ras-related GTP-binding protein C; RRAGC; small GTPase homolog; small GTPase, homolog; TIB929
Gene Aliases: AU041672; GTR2; RAGC; RRAGC; TIB929; YGR163W
UniProt ID: (Human) Q9HB90, (Mouse) Q99K70
Entrez Gene ID: (Human) 64121, (Mouse) 54170, (Rat) 298514
transcription, DNA-templated
apoptotic process
cell cycle arrest
small GTPase mediated signal transduction
RNA splicing
regulation of autophagy
cell growth
macroautophagy
regulation of TOR signaling
positive regulation of TOR signaling
cellular response to amino acid starvation
cellular protein localization
response to amino acid
cellular response to amino acid stimulus
regulation of TORC1 signaling
cellular response to starvation
biological_process
metabolic process
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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