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Bethyl Laboratories
RRAGC/RagC Polyclonal Antibody
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FIGURE: 1 / 2
RRAGC/RagC Antibody (A304-299A) in WB
Detection of human and mouse RRAGC/RagC by western blot. Samples: Whole cell lysate (50 µg) from HeLa, HEK293T, Jurkat, mouse TCMK-1, and mouse NIH 3T3 cells. Antibody: Affinity purified rabbit anti-RRAGC/RagC antibody (Product # A304-299A) (lot A304-299A-1) used for WB at 0.4 µg/mL. Detection: Chemiluminescence with an exposure time of 30 seconds.
Product Details
A304-299A
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Region between residue 1 to 50 of Human Ras-Related GTP Binding C.
Conjugate
Form
Liquid
Concentration
1 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
phosphate/tris citrate, pH 7-8
Contains
0.09% sodium azide
Storage conditions
4°C
Shipping conditions
Ambient (domestic); Wet ice (international)
Product Specific Information
The recommended shelf life for this product is 1 year from date of receipt.
Target Information
RRAGC (Ras-related GTP-binding protein C) is a monomeric guanine nucleotide-binding protein that plays a crucial role in the cellular response to amino acid availability through regulations of the mTORC1 signaling cascade. RRAGC forms a heterodimer with RRAGA and RRAGB and is primarily localized to the cytoplasm. It cycles between an inactive GTP-bound and an active GDP-bound form. RRAGC, in its active form, participates in the re-localization of mTORC1 to the lysosomes and its subsequent activation by the GTPase RHEB. This re-localization is a crucial step in the activation of the TOR signaling cascade by amino acids.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: GTPase-interacting protein 2; Rag C; Rag C protein; Ras-related GTP binding C; Ras-related GTP-binding protein C; RRAGC; small GTPase homolog; small GTPase, homolog; TIB929
Gene Aliases: AU041672; GTR2; RAGC; RRAGC; TIB929; YGR163W
UniProt ID: (Human) Q9HB90, (Mouse) Q99K70
Entrez Gene ID: (Human) 64121, (Mouse) 54170
transcription, DNA-templated
apoptotic process
cell cycle arrest
small GTPase mediated signal transduction
RNA splicing
regulation of autophagy
cell growth
macroautophagy
regulation of TOR signaling
positive regulation of TOR signaling
cellular response to amino acid starvation
cellular protein localization
response to amino acid
cellular response to amino acid stimulus
regulation of TORC1 signaling
cellular response to starvation
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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