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Proteintech
RRAS Polyclonal Antibody
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Product Details
27457-1-AP
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
RRAS Fusion Protein Ag26538 (145-218 aa encoded by BC016318)
Conjugate
Form
Liquid
Concentration
0.4 mg/mL
Amount
60 µg
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Wet ice (domestic); Dry ice (international)
Product Specific Information
Immunogen sequence: DLESQRQVP RSEASAFGAS HHVAYFEASA KLRLNVDEAF EQLVRAVRKY QEQELPPSPP SAPRKKGGGC PCVLL (145-218 aa encoded by BC016318)
Target Information
The Ras superfamily of small GTPases includes the Ras, Rho, Arf, Rab, and Ran families. Ras-regulated signal pathways control such as actin cytoskeletal integrity, proliferation, differentiation, cell adhesion, apoptosis, and cell migration. These GTPases function as molecular switches that control eukaryotic cell function by cycling between two interconvertible forms, a GDP-bound inactive form and a GTP-bound active form. The binding of GTP leads to a conformational change in the downstream effector-binding domain of the G-protein. The small GTPases are monomeric G-proteins with molecular masses over the range 20-30 kDa. Ras is attached to the cell membrane by prenylation. Mutations in the Ras family of proto-oncogenes (comprising H-Ras, N-Ras and K-Ras) are very common, being found in 20% to 30% of all human tumours. The frequency of RAS mutations is among the highest for any gene in human cancer. K-ras mutations occur frequently in non-small-cell lung, colorectal, and pancreatic carcinomas; H-ras mutations are common in bladder, kidney, and thyroid carcinomas; N-ras mutations are found in melanoma, hepatocellular carcinoma, and hematologic malignancies.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: oncogene RRAS; p23; ras family small GTP binding protein R-Ras; Ras-related protein R-Ras; related RAS viral (r-ras) oncogene homolog; RRAS; small GTP binding protein
Gene Aliases: R-Ras; RRAS; RRAS1
UniProt ID: (Human) P10301
Entrez Gene ID: (Human) 6237
leukocyte differentiation
signal transduction
Ras protein signal transduction
positive regulation of endothelial cell migration
cell migration
Schwann cell migration
positive regulation of angiogenesis
regulation of protein kinase B signaling
face morphogenesis
regulation of ERK1 and ERK2 cascade
negative regulation of Schwann cell migration
positive regulation of endothelial cell-matrix adhesion via fibronectin
positive regulation of vasculogenesis
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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