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Proteintech
RRM1 Polyclonal Antibody
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Product Details
10526-1-AP
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Non-human primate,
Rat
Published species
Human,
Xenopus
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
RRM1 Fusion Protein Ag0789 (593-792 aa encoded by BC006498)
Conjugate
Form
Liquid
Concentration
0.22 mg/mL
Amount
33 µg
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Wet ice (domestic); Dry ice (international)
Product Specific Information
Immunogen sequence: IRNSLLIAP MPTASTAQIL GNNESIEPYT SNIYTRRVLS GEFQIVNPHL LKDLTERGLW HEEMKNQIIA CNGSIQSIPE IPDDLKQLYK TVWEISQKTV LKMAAERGAF IDQSQSLNIH IAEPNYGKLT SMHFYGWKQG LKTGMYYLRT RPAANPIQFT LNKEKLKDKE KVSKEEEEKE RNTAAMVCSL ENRDECLMCG S (593-792 aa encoded by BC006498)
Target Information
RRM1 (Ribonucleotide reductase M1 polypeptide) is one of two non-identical subunits that constitute ribonucleoside-diphosphate reductase, an enzyme which catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides. It provides the precursors necessary for DNA synthesis. RRM1 is involved in carcinogenesis, tumor progression.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: R RRM 1; RI RI RR 1; Ribonucleoside-diphosphate reductase large subunit; Ribonucleoside-diphosphate reductase subunit M1; Ribonucleotide reductase large subunit; ribonucleotide reductase M1 polypeptide; ribonucleotide reductase, R1 subunit; RIR 1; unnamed protein product
Gene Aliases: PEOB6; R1; RIR1; RnrM1; RR1; RRM1
UniProt ID: (Human) P23921, (Mouse) P07742
Entrez Gene ID: (Human) 6240, (Rat) 685579, (Mouse) 20133
nucleotide binding
catalytic activity
ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor
protein binding
ATP binding
oxidoreductase activity
purine nucleotide binding
identical protein binding
ribonucleoside-diphosphate reductase activity
disordered domain specific binding
molecular_function
oxidoreductase
reductase
metabolite interconversion enzyme
DNA synthesis involved in DNA repair
pyrimidine nucleobase metabolic process
mitochondrial DNA replication
DNA repair
male gonad development
ribonucleoside diphosphate metabolic process
deoxyribonucleotide biosynthetic process
2'-deoxyribonucleotide biosynthetic process
response to ionizing radiation
positive regulation of G2/M transition of mitotic cell cycle
cell proliferation in forebrain
protein heterotetramerization
retina development in camera-type eye
positive regulation of G0 to G1 transition
positive regulation of G1/S transition of mitotic cell cycle
mitotic cell cycle
DNA replication
protein oligomerization
oxidation-reduction process
metabolic process
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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