PA5-30972 targets RRP4 in IF, IHC (P), and WB applications and shows reactivity with Human samples.
The PA5-30972 immunogen is recombinant fragment corresponding to a region within amino acids 1 and 277 of Human RRP4.
Store product as a concentrated solution. Centrifuge briefly prior to opening the vial. For short-term storage (1-2 weeks), product can be stored at 4°C. For long-term storage, aliquot and store product at -20° C or below, avioiding multiple freeze-thaw cycles.
Component of the exosome 3'->5' exoribonuclease complex, a complex that degrades inherently unstable mRNAs containing AU-rich elements (AREs) within their 3' untranslated regions. Required for the 3'processing of the 7S pre-RNA to the mature 5.8S rRNA. Has a 3'-5' exonuclease activity.
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Protein Aliases: 3' 5' exoribonuclease (RRP4); 3'-5'-exoribonuclease; Exosome complex component RRP4; exosome complex exonuclease RRP4; Exosome component 2; homolog of yeast RRP4 (ribosomal RNA processing 4); homolog of yeast RRP4 (ribosomal RNA processing 4), 3' 5' exoribonuclease (RRP4); homolog of yeast RRP4 (ribosomal RNA processing 4), 3'-5'-exoribonuclease; hRrp4p; Ribosomal RNA-processing protein 4; Rrp4p
Gene Aliases: EXOSC2; hRrp4p; p7; RRP4; Rrp4p
UniProt ID: (Human) Q13868
Entrez Gene ID: (Human) 23404