Proteintech

RRP8 Polyclonal Antibody

View all (8) Cerebral Protein 1 antibodies

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Datasheet
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RRP8 Polyclonal Antibody

Product Details

20129-1-AP

Applications
Tested Dilution
Publications

Western Blot (WB)

1:500-1:3,000
-

Immunohistochemistry (Paraffin) (IHC (P))

1:20-1:200
-

Immunocytochemistry (ICC/IF)

1:10-1:100
-
Product Specifications

Species Reactivity

Human, Mouse, Rat

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

RRP8 Fusion Protein Ag13994 (97-456 aa encoded by BC001071)
View immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.5 mg/mL

Purification

Antigen affinity chromatography

Storage buffer

PBS, pH 7.3, with 50% glycerol

Contains

0.02% sodium azide

Storage conditions

-20°C

Shipping conditions

Wet ice (domestic); Dry ice (international)

Product Specific Information

Immunogen sequence: QKQGPPCSD SEEEVERKKK CHKQALVGSD SAEDEKRKRK CQKHAPINSA QHLDNVDQTG PKAWKGSTTN DPPKQSPGST SPKPPHTLSR KQWRNRQKNK RRCKNKFQPP QVPDQAPAEA PTEKTEVSPV PRTDSHEARA GALRARMAQR LDGARFRYLN EQLYSGPSSA AQRLFQEDPE AFLLYHRGFQ SQVKKWPLQP VDRIARDLRQ RPASLVVADF GCGDCRLASS IRNPVHCFDL ASLDPRVTVC DMAQVPLEDE SVDVAVFCLS LMGTNIRDFL EEANRVLKPG GLLKVAEVSS RFEDVRTFLR AVTKLGFKIV SKDLTNSHFF LFDFQKTGPP LVGPKAQLSG LQLQPCLYKR R (97-456 aa encoded by BC001071)

Target Information

Essential component of the eNoSC (energy-dependent nucleolar silencing) complex, a complex that mediates silencing of rDNA in response to intracellular energy status and acts by recruiting histone-modifying enzymes. The eNoSC complex is able to sense the energy status of cell: upon glucose starvation, elevation of NAD(+)/NADP(+) ratio activates SIRT1, leading to histone H3 deacetylation followed by dimethylation of H3 at 'Lys-9' (H3K9me2) by SUV39H1 and the formation of silent chromatin in the rDNA locus. In the complex, RRP8 binds to H3K9me2 and probably acts as a methyltransferase. Its substrates are however unknown.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: Cerebral protein 1; Cerebral protein 1 homolog; HUCE1; hucep1; Nucleomethylin; Ribosomal RNA-processing protein 8; RRP-8; RRP8 methyltransferase homolog

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Gene Aliases: 1500003O22Rik; 2900001K19Rik; AW538116; hucep-1; KIAA0409; NML; RGD1308302; RRP8

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UniProt ID: (Human) O43159, (Mouse) Q9DB85, (Rat) Q5U4F0

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Entrez Gene ID: (Human) 23378, (Mouse) 101867, (Rat) 308911

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Function(s)
protein binding S-adenosylmethionine-dependent methyltransferase activity methylated histone binding poly(A) RNA binding rRNA (adenine-N6,N6-)-dimethyltransferase activity protein C-terminal carboxyl O-methyltransferase activity tRNA (guanine-N2-)-methyltransferase activity methyltransferase activity C-methyltransferase activity N-methyltransferase activity O-methyltransferase activity S-methyltransferase activity RNA methyltransferase activity mRNA methyltransferase activity tRNA methyltransferase activity protein methyltransferase activity 2-polyprenyl-6-methoxy-1,4-benzoquinone methyltransferase activity rRNA methyltransferase activity rRNA (uridine-2'-O-)-methyltransferase activity rRNA (adenine-N6-)-methyltransferase activity DNA-methyltransferase activity tRNA (guanine-N1-)-methyltransferase activity rRNA (cytosine-C5-)-methyltransferase activity selenocysteine methyltransferase activity arginine N-methyltransferase activity protein-arginine N-methyltransferase activity lysine N-methyltransferase activity protein-lysine N-methyltransferase activity tRNA (uracil) methyltransferase activity tRNA (guanine) methyltransferase activity tRNA (adenine) methyltransferase activity tRNA (cytosine) methyltransferase activity tRNA (cytosine-5-)-methyltransferase activity tRNA (adenine-N1-)-methyltransferase activity rRNA (adenine) methyltransferase activity rRNA (cytosine) methyltransferase activity rRNA (guanine) methyltransferase activity rRNA (uridine) methyltransferase activity transferase activity protein C-terminal leucine carboxyl O-methyltransferase activity 1-phenanthrol methyltransferase activity protein-arginine N5-methyltransferase activity methylarsonite methyltransferase activity dimethylarsinite methyltransferase activity 4,5-dihydroxybenzo(a)pyrene methyltransferase activity 1-hydroxypyrene methyltransferase activity 1-hydroxy-6-methoxypyrene methyltransferase activity demethylmenaquinone methyltransferase activity cobalt-precorrin-6B C5-methyltransferase activity cobalt-precorrin-7 C15-methyltransferase activity cobalt-precorrin-5B C1-methyltransferase activity cobalt-precorrin-3 C17-methyltransferase activity dimethylamine methyltransferase activity hydroxyneurosporene-O-methyltransferase activity tRNA (adenine-57, 58-N(1)-) methyltransferase activity methylamine-specific methylcobalamin:coenzyme M methyltransferase activity trimethylamine methyltransferase activity methanol-specific methylcobalamin:coenzyme M methyltransferase activity monomethylamine methyltransferase activity P-methyltransferase activity Se-methyltransferase activity 2-phytyl-1,4-naphthoquinone methyltransferase activity tRNA (uracil-2'-O-)-methyltransferase activity tRNA (cytosine-2'-O-)-methyltransferase activity phosphomethylethanolamine N-methyltransferase activity tRNA (cytosine-3-)-methyltransferase activity rRNA (cytosine-2'-O-)-methyltransferase activity rRNA (cytosine-N4-)-methyltransferase activity trihydroxyferuloyl spermidine O-methyltransferase activity
Process(es)
chromatin silencing at rDNA transcription, DNA-templated rRNA processing covalent chromatin modification methylation cellular response to glucose starvation regulation of transcription by glucose positive regulation of cell cycle arrest intrinsic apoptotic signaling pathway by p53 class mediator regulation of transcription, DNA-templated chromatin modification
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