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Bethyl Laboratories
RRP8 Polyclonal Antibody
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FIGURE: 1 / 1
RRP8 Antibody (A304-201A) in WB
Detection of human RRP8 by western blot. Samples: Whole cell lysate (50 µg) from 293T, HeLa, and Jurkat cells. Antibodies: Affinity purified rabbit anti-RRP8 antibody (Product # A304-201A) (lot A304-201A-1) used for WB at 0.1 µg/mL. Detection: Chemiluminescence with an exposure time of 3 minutes.
Product Details
A304-201A
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Region between residue 1 to 50 of Human Ribosomal RNA Processing 8.
Conjugate
Form
Liquid
Concentration
1 mg/mL
Amount
100 µg
Purification
Antigen affinity chromatography
Storage buffer
phosphate/tris citrate, pH 7-8
Contains
0.09% sodium azide
Storage conditions
4°C
Shipping conditions
Ambient (domestic); Wet ice (international)
Product Specific Information
The recommended shelf life for this product is 1 year from date of receipt.
Target Information
Essential component of the eNoSC (energy-dependent nucleolar silencing) complex, a complex that mediates silencing of rDNA in response to intracellular energy status and acts by recruiting histone-modifying enzymes. The eNoSC complex is able to sense the energy status of cell: upon glucose starvation, elevation of NAD(+)/NADP(+) ratio activates SIRT1, leading to histone H3 deacetylation followed by dimethylation of H3 at 'Lys-9' (H3K9me2) by SUV39H1 and the formation of silent chromatin in the rDNA locus. In the complex, RRP8 binds to H3K9me2 and probably acts as a methyltransferase. Its substrates are however unknown.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: Cerebral protein 1; HUCE1; hucep1; KIAA0409; Nucleomethylin; ribosomal RNA processing 8, methyltransferase, homolog; Ribosomal RNA-processing protein 8; RRP-8; RRP8 methyltransferase homolog
Gene Aliases: hucep-1; KIAA0409; NML; RRP8
UniProt ID: (Human) O43159
Entrez Gene ID: (Human) 23378
chromatin silencing at rDNA
chromatin organization
rRNA processing
methylation
cellular response to glucose starvation
negative regulation of cell cycle
negative regulation of transcription, DNA-templated
regulation of transcription by glucose
intrinsic apoptotic signaling pathway by p53 class mediator
energy homeostasis
regulation of G1 to G0 transition
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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